Gabriella Salinas-Riester

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As the human life span increases, the number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice(More)
Extinction learning refers to the phenomenon that a previously learned response to an environmental stimulus, for example, the expression of an aversive behaviour upon exposure to a specific context, is reduced when the stimulus is repeatedly presented in the absence of a previously paired aversive event. Extinction of fear memories has been implicated with(More)
Increasing evidence suggests an important function of the β-amyloid precursor protein (APP) in malignant disease in humans; however, the biological basis for this evidence is not well understood at present. To understand the role of APP in transformed pluripotent stem cells, we studied its expression levels in human testicular germ cell tumors using patient(More)
Autologous hematopoietic stem cell transplantation (aHSCT) has been used as a therapeutic approach in multiple sclerosis (MS). However, it is still unclear if the immune system that emerges from autologous CD34+ hematopoietic progenitor cells (HPC) of MS patients is pre-conditioned to re-develop the proinflammatory phenotype. The objective of this article(More)
  • Posterpreise, . Preis, +21 authors T. Szarvas
  • Der Pathologe
  • 2012
Institut für Pathologie, Universität Witten/Herdecke, Wuppertal Institut für Pathologie und Neuropathologie, Universität Duisburg-Essen, Essen Klinik für Urologie, Universität Duisburg-Essen, Essen Institut für Pharmakologie und klinische Pharmakologie, Universität Duisburg-Essen, Essen Institut für Anatomie, Universität Duisburg-Essen, Essen Klinik(More)
16-19 June 2011, Heidelberg, Germany EMBO Fellows Meeting 2011 The p110δ isoform of PI3K, a new component of the TLR4 signalosome, protects from endotoxin lethality by sorting TLR4 signaling from plasma membrane into endosomes Key points • p110δ PI3K is recruited to the actived TLR4 and synthesizes PIP3 from PIP2 at the plasma membrane. • Spatio-temporal(More)
Prolonged and sustained stimulation of the hypothalamo-pituitary-adrenal axis have adverse effects on numerous brain regions, including the cerebellum. Motor coordination and motor learning are essential for animal and require the regulation of cerebellar neurons. The G-protein-coupled cannabinoid CB1 receptor coordinates synaptic transmission throughout(More)
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