Gabriella Juhasz-Vedres

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Neurotransmitter release and spontaneous action potentials during cochlear inner hair cell (IHC) development depend on the activity of Ca(v)1.3 voltage-gated L-type Ca(2+) channels. Their voltage- and Ca(2+)-dependent inactivation kinetics are slower than in other tissues but the underlying molecular mechanisms are not yet understood. We found that(More)
Background In L-type voltage-gated calcium channels (VGCCs) the long C-terminal tail contains several sites for modulation by protein-protein interaction. CaV1.3 VGCCs (CaV1.3L) activate at negative voltages and support sinoatrial node pacemaking and hearing, and shape neuronal excitability. In CaV1.3L an intermolecular automodulatory C-terminal interaction(More)
Calcium channel β subunits (CaVβs) are essential cytoplasmic components of voltage-gated calcium channels (VGCCs) affecting their gating and targeting. CaVβs bind with high affinity to the cytoplasmic loop between transmembrane segments I and II of the α1 subunit (loop-I-II). To identify new proteins that modulate VGCCs by interaction with CaVβs we(More)
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