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Additional Chromosome Abnormalities, BCR-ABL Tyrosine Kinase Domain Mutations and Clinical Outcome in Hungarian Tyrosine Kinase Inhibitor-Resistant Chronic Myelogenous Leukemia Patients
Background: Additional chromosome abnormalities (ACAs), mutations of the BCR-ABL tyrosine kinase domain (TKD) and BCR-ABL splice variants may cause resistance to first- and second-generation tyrosine… Expand
[Role of the activating mutation Val617Phe of Janus kinase 2 gene in myeloproliferative diseases and significance of its detection].
The Val617Phe point mutation of Janus kinase 2 gene is believed to participate in the pathogenesis of myeloproliferative syndrome characterised by the clonal alteration of hematopoietic stem cells.… Expand
[Complex molecular genetic algorithm in the diagnosis of myeloproliferative neoplasms].
- T. Krähling, Katalin Balassa, +10 authors H. Andrikovics
- Medicine, Biology
- Orvosi hetilap
- 20 December 2014
INTRODUCTION Mutations in Janus kinase 2, calreticulin and thrombopoietin receptor genes have been identified in the genetic background of Philadelphia chromosome negative, "classic"… Expand
Simultaneous proteosome inhibition and heat shock protein induction by bortezomib is beneficial in experimental pancreatitis.
The proteosome inhibitor bortezomib is used in the treatment of patients with multiple myeloma. Proteosomes are responsible for the degradation of I-kappaB, the inhibitory protein of transcription… Expand
Blast colony‐forming cell binding from CML bone marrow, or blood, on stromal layers pretreated with G‐CSF or SCF
Blast colony‐forming cells (CFU‐BL) represent a specific subpopulation of special primitive progenitors characterized by colony formation only in close contact with a preformed stromal layer. CFU‐BL… Expand
IL-6 and lipoprotein(a) [LP(a)] concentrations are related only in patients with high APO(a) isoforms in monoclonal gammopathy.
We have investigated the influence of apo(a) genetics on the relationship between interleukin (IL)-6, and lipoprotein (a) [Lp(a)] levels in 154 patients with monoclonal gammopathy and 189 healthy… Expand
Salvage chemotherapy with donor lymphocyte infusion and STI 571 in a patient relapsing with B-lymphoblastic phase chronic myeloid leukemia after allogeneic bone marrow transplantation
- L. Gopcsa, A. Barta, A. Bányai, J. Dolgos, G. Halm, K. Pálóczi
- Biology, Medicine
- Pathology Oncology Research
Relapse is the main cause of treatment failure following hematopoietic stem cell transplantation for blastic phase chronic myeloid leukemia. Treatment options including donor lymphocyte infusion,… Expand
[Prognostic significance of age and karyotype in the treatment of acute myeloid leukemia: results at our center].
INTRODUCTION Treatment outcome in patients with acute myeloid leukemia are determined by prognostic factors. AIM AND METHODS Between January 1996 and December 2001 160 patients were treated with… Expand