Gabriele Wander Ruas

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BACKGROUND Water is an important factor on the appearance and function of the skin and, when dehydrated, it becomes rough and flaky. The measurement of stratum corneum hydration is widely employed to verify the moisture effect of topical products. AIMS This study has evaluated in vivo the stratum corneum hydration, by the electrical measurements of skin,(More)
Papain is a thiol proteolytic enzyme widely used in dermatology that found applications in wound treatment. Recently, papain was also used as absorption enhancer which can modify the peptide/ protein material in the bilayer domain. We investigated papain safety using human skin that was exposed to papain in vitro at different times: 4, 24 and 48 hours. The(More)
Papain is a proteolytic enzyme used in topical formulations for peeling and treatment of burns, wounds and scars. It is also used as progressive depilatory agent and as cutaneous absorption enhancer. This work was aimed at validating a spectrofluorimetic method to quantify the activity of papain in semisolid pharmaceutical dosage forms.(More)
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