Gabriele Schreiber

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The cell division cycle orchestrates cellular growth and division. The machinery underpinning the cell division cycle is well characterized, but the actual cue(s) driving the cell division cycle remains unknown. In rapidly growing and dividing yeast cells, this cue has been proposed to be cell size. Presumably, a mechanism communicating cell size acts as(More)
Cell penetrating peptides (CPP) and cationic antibacterial peptides (CAP) have similar physicochemical properties and yet it is not understood how such similar peptides display different activities. To address this question, we used Iztli peptide 1 (IP-1) because it has both CPP and CAP activities. Combining experimental and computational modeling of the(More)
The budding yeast genome comprises roughly 6000 genes generating a number of about 10 000 mRNA copies, which gives a general estimation of 1-2 mRNA copies generated per gene. What does this observation implicate for cellular processes and their regulation? Whether the number of mRNA molecules produced is important for setting the amount of proteins(More)
Communication between cells is a ubiquitous feature of cell populations and is frequently realized by secretion and detection of signaling molecules. Direct visualization of the resulting complex gradients between secreting and receiving cells is often impossible due to the small size of diffusing molecules and because such visualization requires(More)
Institute of Biology, Humboldt University of Berlin, Invalidenstraße 42, 10115 Berlin, Germany; Department of Biochemistry and Molecular Biology, Indiana University, Bloomington, Indiana 47405, USA; Max-Delbrück Centrum for Molecular Medicine, Robert-Rössle Straße 10, 13125 Berlin, Germany; Center for Membrane Pumps in Cells and Disease PUMPKIN, Danish(More)
The ATP binding cassette (ABC) transporter Aus1 is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae and is required for sterol uptake. These observations suggest that Aus1 promotes the translocation of sterols across membranes, but the precise transport mechanism has yet to be identified. In this(More)
Bei einer Patientin mit im 43. Lebensjahr nachgewiesenen „angioid streaks” hatten sich seit dem 21. Lebensjahr umschriebene, atrophische gelblich-graue Hautveränderungen am Hals, in den Axillen und weiteren Beugeregionen entwickelt. Trotz der sehr charakteristischen Hautveränderungen wurde die Diagnose eines Pseudoxanthoma elasticum erst 22 Jahre nach(More)
Sic1, cyclin-dependent kinase inhibitor of budding yeast, is synthesized in anaphase and largely degraded at the S-phase onset to regulate timing of DNA synthesis. Sic1 interacts with phase-specific B-type cyclin (Clb)-kinase (Cdk1) complexes, central regulators in cell cycle control. Its appearance is timed to mediate reduction in kinase activities at(More)
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