Gabriele Meliadò

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OBJECTIVES Delineation of clinical target volume (CTV) is still controversial in glioblastomas. In order to assess the differences in volume and shape of the radiotherapy target, the use of pre-operative vs post-operative/pre-radiotherapy T(1) and T(2) weighted MRI was compared. METHODS 4 CTVs were delineated in 24 patients pre-operatively and(More)
PURPOSE To propose a magnetic resonance imaging (MRI) quality assurance procedure that can be used for multicenter comparison of different MR scanners for quantitative diffusion-weighted imaging (DWI). MATERIALS AND METHODS Twenty-six centers (35 MR scanners with field strengths: 1T, 1.5T, and 3T) were enrolled in the study. Two different DWI acquisition(More)
To test 3T proton magnetic resonance spectroscopy (1H-MRS) for breast mass lesions. Patients with BI-RADS 4–5 lesions at mammography/ultrasound were prospectively enrolled. After contrast-enhanced breast MRI, single-voxel MRS (point-resolved volume selection, PRESS); pencil-beam shimming; volume of interest 1 cm3; TR/TE = 3000/135 ms) was performed. Spectra(More)
Intensity modulated radiation therapy (IMRT) is increasingly employed in glioblastoma (GBM) treatment. The present work aimed to assess which clinical-dosimetric scenario could benefit the most from IMRT application, with respect to three-dimensional conformal radiation therapy (3D-CRT). The number of organs at risk (OARs) overlapping the planning target(More)
BACKGROUND We report the results of a single-institution, phase II trial of accelerated partial breast irradiation (APBI) using a single dose of intraoperative electron radiation therapy (IOERT) in patients with low-risk early stage breast cancer. METHODS AND MATERIALS A cohort of 226 patients with low-risk, early stage breast cancer were treated with(More)
The Specific Absorption Rate (SAR) distribution pattern visualization by a matrix of E-field light-emitting sensors has demonstrated to be a useful tool to evaluate the characteristics of the applicators used in deep regional hyperthermia and to perform a quality assurance programme. A method to quantify the SAR from photographs of the sensor array--the(More)
INTRODUCTION The aim of this work was to assess the role of 3T-MR spectroscopy (MRS) in the multi-parametric MRI evaluation of breast lesions, using a pattern-recognition based classification method. METHODS 291 patients (301 lesions, median 2.3cm3) were enrolled in the study (age 18-85y, mean 54.2y). T1-TSE (TR/TE=400/10ms) and T2-STIR imaging(More)
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