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We consider the problem of finding two-dimensional cutting patterns for glass sheets in order to produce rectangular elements requested by customers. The number of needed sheets, and therefore the waste, is to be minimized. The cutting facility requires three-staged guil-lotineable cutting patterns, and in addition, a plan for loading produced elements on(More)
Cognitive impairment in drug-dependent patients receiving methadone (MMP) maintenance treatment has been reported previously. We assessed cognitive functioning after at least 14 days of stable substitution treatment with buprenorphine (BUP) or MMP and after 8 to 10 weeks. We performed a randomized, nonblinded clinical trial in 59 drug-dependent patients(More)
We carried out dynamic [(18)F]fallypride PET scans to measure cerebral dopamine D2/3 receptor availability in a 23-year old patient experiencing a severe withdrawal syndrome upon voluntary abstinence from "Spice", a pre-packaged herbal smoking thought to contain synthetic cannabinoids. Upon admission to the clinic, the patient experienced craving, affective(More)
Positron emission tomography (PET) shows reduced binding of the dopamine D(2/3) antagonist [(11) C]raclopride in striatum of withdrawn psychostimulant abusers, but not consistently in patients with alcohol dependence (AD). We make first use of the high affinity ligand [(18) F]fallypride to obtain serial measures of D(2/3) receptor availability in striatal(More)
Multiple lines of evidence suggest that the endocannabinoid system is implicated in the development of alcohol dependence. In addition, in animal models, the cannabinoid receptor 1 blocker rimonabant was found to decrease alcohol consumption, possibly by indirect modulation of dopaminergic neurotransmission. This was a 12-week double-blind,(More)
Cognitive impairment in drug-dependent patients receiving methadone maintenance treatment has been reported previously, although the literature is limited and results remain controversial. Long-term effects under stable methadone maintenance treatment (MMT) and the possibility of improvement in cognitive performance during long-term substitution treatment(More)
— Many graph problems seek subgraphs of minimum weight that satisfy a set of constraints. Examples include the minimum spanning tree problem (MSTP), the degree-constrained minimum spanning tree problem (d-MSTP), and the traveling salesman problem (TSP). Low-weight edges predominate in optimum solutions to such problems, and the performance of evolutionary(More)
The multiple sequence alignment problem (MSA) can be re-formulated as the problem of finding a maximum weight trace in an alignment graph, which is derived from all pairwise alignments. We improve the alignment graph by adding more global information. A new construction heuristic and an evolutionary algorithm with specialized operators are proposed and(More)
This diploma thesis presents a new approach for multiple sequence alignment (MSA), which tries to overcome some of the main problems of existing strategies. At first it gives a formal definition of the MSA problem, elucidates occuring difficulties and describes existing MSA algorithms particularly with regard to evolutionary algorithms. Then the maximum(More)
INTRODUCTION One of the proposed psychobiological pathways of craving attributes the desire for drinking in the context of tension, discomfort or unpleasant emotions, to "negative" (or "relief") craving. The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping(More)