Gabriela Cabral

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Centrosome function in cell division requires their duplication, once, and only once, per cell cycle. Underlying centrosome duplication are alternating cycles of centriole assembly and separation. Work in vertebrates has implicated the cysteine protease separase in anaphase-coupled centriole separation (or disengagement) and identified this as a key step in(More)
The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. Five conserved proteins for centriole duplication have been identified. Two of them, SAS-5 and SAS-6, physically interact with each other and are codependent for their targeting to procentrioles. However, it remains unclear how these two(More)
Figure 1. SPD-5 incorporates throughout the volume of the PCM. (A) Schematic of assay to determine spatial dynamics of PCM assembly. Centrosomal GFP signal is bleached during centrosome maturation. Three possible outcomes for the pattern of new protein incorporation are shown. (B) Representative images of GFP::SPD-5 before and after bleaching/maturation.(More)
The centromere appears as a single constriction at mitotic metaphase in most eukaryotic chromosomes. Holokinetic chromosomes are the exception to this rule because they do not show any centromeric constrictions. Holokinetic chromosomes are usually forgotten in most reviews about centromeres, despite their presence in a number of animal and plant species.(More)
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