Gabriela C. Lopes

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Cerebrovascular and cardiovascular diseases are the leading causes of death and disability worldwide. They are complex disorders resulting from the interplay of genetic and environmental factors, and may share several susceptibility genes. Several recent studies have implicated variants of the Kalirin (KALRN) gene with susceptibility to cardiovascular and(More)
The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations.(More)
We hereby propose a novel approach to the identification of ischemic stroke (IS) susceptibility genes that involves converging data from several unbiased genetic and genomic tools. We tested the association between IS and genes differentially expressed between cases and controls, then determined which data mapped to previously reported linkage peaks and(More)
Sirs: Randomised controlled clinical trials (RCT) offer the highest level of evidence for treatment recommendations. However, the impact of RCT in changing current practice is variable and the implementation of clinical recommendations is often insufficient [3, 7–9]. We evaluated the impact of 2 RCT of anticoagulation in acute cerebral vein and dural sinus(More)
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