Gabriela Bastos Cabral

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HIV-1 tropism determination is necessary prior to CCR5 antagonist use as antiretroviral therapy. Genotypic prediction of coreceptor use is a practical alternative to phenotypic tests. Cell DNA and plasma RNA-based prediction has shown discordance in many studies. We evaluate paired cell and plasma either as single or replicate V3 sequences to assess(More)
Determination of human immunodeficiency virus tropism has contributed to the understanding of the pathogenesis of HIV and is necessary prior to the use of CCR5 antagonists. Replicate V3 sequences may generate different sequences and improve viral tropism prediction. The diversity of HIV was evaluated to access its influence on prediction. Plasma RNA was(More)
Genotypic prediction of HIV-1 tropism has been considered a practical surrogate for phenotypic tests and recently an European Consensus has set up recommendations for its use in clinical practice. Twenty-five antiretroviral-experienced patients, all heavily treated cases with a median of 16 years of antiretroviral therapy, had viral tropism determined by(More)
INTRODUCTION Universal antiretroviral treatment with sustained viral suppression benefits patients and reduces HIV transmission. Effectiveness of therapy may be limited by antiretroviral drug resistance. Information on the resistance profile at treatment failure and its impact on antiretroviral drugs may subsidize subsequent treatment strategies. METHODS(More)
O225 Table 1. Baseline characteristics of study population Total (n 127) Naı̈ve patients (n 100) Treated patients (n 27) Sex Male 103 (81.1) 87 (87.0) 16 (59.3) Age at diagnosis Median (IQR) 40 (30 to 50) 47 (31 to 50) 34 (25 to 43) Year of diagnosis Median (IQR) 2012 (2009 to 2015) 2014 (2012 to 2015) 2005 (2000 to 2011) Country of origin Aruba 74 (58.3)(More)
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