Learn More
The EGFR monoclonal antibody cetuximab is the only approved targeted agent for treating head and neck squamous cell carcinoma (HNSCC). Yet resistance to cetuximab has hindered its activity in this disease. Intrinsic or compensatory HER3 signaling may contribute to cetuximab resistance. To investigate the therapeutic benefit of combining MM-121/SAR256212, an(More)
A number of methods for temporal alignment, feature extraction and clustering of electrocardiographic signals are proposed. The ultimate aim of the paper is to find a method to automatically reduce the quantity of beats to examine in a long-term electrocardiographic signal, known as Holter signal, without loss of valuable information for the diagnosis.(More)
This paper describes an approach to classify people , groups of people and luggage in the halls of an airport. The algorithm is included into a surveillance system which tracks and classifies objects and transmits this information to a higher computational level which fuses the information of several cameras covering overlapping areas. Two kind of features(More)
In this paper, a method to automatically extract the main information from a long-term electrocardiographic signal is presented. This method is based on techniques of pattern recognition applied to speech processing, like dynamic time warping, and trace segmentation. In order to fulfill this objective, a clustering process is applied to the set of beats(More)
This paper describes the recognition of container code characters. The system has to deal with outdoor images which usually have damaged characters and obtain an answer in real time. Tophat transformation, equalization and adaptive cropping have been applied so as to reduce the noise and correct the inclusion box. The training corpus is artificially grown(More)
Heregulin-driven ERBB3 signaling has been implicated as a mechanism of resistance to cytotoxic and antiendocrine therapies in preclinical breast cancer models. In this study, we evaluated the effects of seribantumab (MM-121), a heregulin-blocking anti-ERBB3 monoclonal antibody, alone and in combination with the aromatase inhibitor letrozole, on cell(More)
BACKGROUND Although heregulin and human epidermal growth factor receptor 3 (HER3) are frequently expressed at high levels in patients with head and neck cancer, their prognostic value remains unclear. The authors explored the prognostic significance of heregulin/HER3 expression in patients with oropharyngeal squamous cell carcinoma (OPSCC), taking into(More)
Glutathione transferases (GSTs) are believed to be a major detoxification system in helminths. We describe the expression and functional analysis of EgGST, a cytosolic GST from Echinococcus granulosus, related to the Mu-class of mammalian enzymes. EgGST was produced as an enzymatically active dimeric protein (rEgGST), with highest specific activity towards(More)