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In this paper, the algorithms of the automatic mesh generator NETGEN are described. The domain is provided by a Constructive Solid Geometry (CSG). The whole task of 3D mesh generation splits into four subproblems of special point calculation, edge following, surface meshing and finally volume mesh generation. Surface and volume mesh generation are based on(More)
The shape of neuronal cells strongly resembles botanical trees or roots of plants. To analyze and compare these complex three-dimensional structures it is important to develop suitable methods. We review the so called tree-edit-distance known from theoretical computer science and use this distance to define dissimilarity measures for neuronal cells. This(More)
Mathematical modeling of skin transport is considered a valuable alternative of in-vitro and in-vivo investigations especially considering ethical and economical questions. Mechanistic diffusion models describe skin transport by solving Fick's 2nd law of diffusion in time and space; however models relying entirely on a consistent experimental data set are(More)
Two-photon microscopy in combination with novel fluorescent labeling techniques enables imaging of three-dimensional neuronal morphologies in intact brain tissue. In principle it is now possible to automatically reconstruct the dendritic branching patterns of neurons from 3-D fluorescence image stacks. In practice however, the signal-to-noise ratio can be(More)
A major challenge in computational finance is the pricing of options that depend on a large number of risk factors. Prominent examples are basket or index options where dozens or even hundreds of stocks constitute the underlying asset and determine the dimensionality of the corresponding degenerate parabolic equation. The objective of this article is to(More)
The morphology of presynaptic specializations can vary greatly ranging from classical single-release-site boutons in the central nervous system to boutons of various sizes harboring multiple vesicle release sites. Multi-release-site boutons can be found in several neural contexts, for example at the neuromuscular junction (NMJ) of body wall muscles of(More)