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We observed vertically displaced coastal and river markers after the 27 February 2010 Chilean earthquake [moment magnitude (Mw) 8.8]. Land-level changes range between 2.5 and -1 meters, evident along an approximately 500-kilometers-long segment identified here as the maximum length of coseismic rupture. A hinge line located 120 kilometers from the trench(More)
There are few examples of successful CNS diagnostics owing to our poor understanding of the mechanisms of disease. This article will discuss this and other challenges facing CNS diagnostic development with a focus on Alzheimer's disease, along with a discussion of potential future diagnostic assays that may help in the development of new CNS medications.
PURPOSE Capsaicin-induced dermal blood flow (CIDBF) is a validated biomarker used to evaluate the target engagement of potential calcitonin gene-related peptide-blocking therapeutics for migraine. To characterize the pharmacokinetics (PK) and quantify the inhibitory effects of erenumab (AMG 334) on CIDBF, CIDBF data were pooled from a single- and a(More)
Molecular biomarkers for antipsychotic treatments have been conceptually linked to the measurements of dopamine functions, mostly D(2) receptor occupancy, either by imaging using selective PET/SPECT radioactive tracers or by assessing plasma prolactin levels. A quest for novel biomarkers was recently proposed by various academic, health service, and(More)
The 2015 M w 8.3 Illapel, Chile earthquake is the latest megathrust event on the central segment of that subduction zone. It generated strong ground motions and a large (up to 11 m runup) tsunami which prompted the evacuation of more than 1 million people in the first hours following the event. Observations during recent earthquakes suggest that these(More)
Each year during late winter and spring, grazing sheep and cattle in the State of Tamaulipas in northeastern Mexico develop toxicoses which have been empirically associated to consumption of a toxic plant locally known as moradilla. This investigation was undertaken to determine whether moradilla was a toxic plant not yet reported in Tamaulipas or was an(More)
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