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The effects of prenatal, perinatal and postnatal events on developmental outcome at five to seven years of preterm infants with birthweights appropriate for gestational age were investigated in two separate cohorts: one a longitudinal study of 97 infants, the other a cross-sectional study of 249 infants. Among the prenatal variables, the number of minor(More)
Data on the development of locomotion during the first two years of life were collected for 128 preterm infants (21 with varying degrees of cerebral palsy) and for 111 healthy term infants. Most stages of locomotion occurred at slightly later ages among the neurologically unimpaired preterm infants than among those born at term (age corrected for(More)
BACKGROUND Anemia of prematurity is characterized by low reticulocyte counts and inadequate erythropoietin response, for which many very-low-birth-weight infants receive multiple blood transfusions. We investigated whether early treatment of such infants with recombinant human erythropoietin would reduce their need for transfusions. METHODS We performed a(More)
Intellectual development, speech and school performance of preterm infants with birth weight appropriate for gestational age are reported in two separate investigations: a longitudinal study of 97 preterm children and 93 term children as a control group, and a cross-sectional study of 249 preterm children. Both preterm groups were regarded as high risk(More)
The evaluation of perinatal growth requires different approaches depending on the chronological age of the infant. Basically, three periods of perinatal growth are to be distinguished: Intrauterine period: Growth during this period can be estimated by intrauterine growth standards representing fetal growth parameters at birth. Transitional period: Growth(More)
BACKGROUND The increase in neonatal survival in recent decades has been followed by an increase in later disabilities. This has given rise to many new ethical issues. In different countries, efforts are being made to define ethical guidelines regarding withholding or withdrawing intensive care and end-of-life decisions in critically ill newborn infants.(More)
Sera from 33 newborn infants with gestational ages ranging from 27 to 41 weeks were tested by radioimmunoassay for IgG antibodies to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III. Antibody levels to GBS antigens were positively correlated to gestational age and birthweight. However, only the correlations for anti-Ia and anti-II(More)
We performed a multicenter prospective randomized controlled trial to determine the efficacy and safety of the surfactant preparation, Survanta (Abbott Laboratories, Chicago, USA), for 750–1750 g infants with idiopathic respiratory distress syndrome, (IRDS) receiving assisted ventilation with 40% or more oxygen. One hundred and six eligible infants from the(More)
Two sources of artifactual pulse-oximetry estimation were investigated in 20 neonates. Increased pressure on tissue due to inappropriate sensor fixation was mimicked with a blood pressure cuff. The error in arterial oxygen saturation (pSO2) exceeded 2 SD (> 3%) in 25% subjects at 50 mm Hg which in an ancillary experiment was produced by 11 of 26 nurses(More)