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  • Ravi Kumar Jaiswal, Neelam Jaiswal, Scott P. Bruder, Gabriel Mbalaviele, Daniel R. Marshak, Mark F. Pittenger
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000 (First Publication: 31 March 2000)
  • Adult human mesenchymal stem cells are primary, multipotent cells capable of differentiating to osteocytic, chondrocytic, and adipocytic lineages when stimulated under appropriate conditions. ToContinue Reading
  • Gabriel Mbalaviele, Hui Chen, Brendan F Boyce, Gregory R. Mundy, T. Yoneda
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1995 (First Publication: 1 June 1995)
  • A critical step in bone resorption is the fusion of mononuclear osteoclast precursors to form multinucleated osteoclasts. However, little is known of the molecular mechanisms that are responsible forContinue Reading
  • Eric T Baima, Julia A. Guzova, +12 authors Gabriel Mbalaviele
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2010 (First Publication: 18 February 2010)
  • The classical nuclear factor κB (NF-κB) signaling pathway is under the control of the IκB kinase (IKK) complex, which consists of IKK-1, IKK-2, and NF-κB essential modulator (NEMO). This complex isContinue Reading
  • Gabriel Mbalaviele, Adele M. Pauley, +10 authors Jaime L. Masferrer
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2010 (First Publication: 1 May 2010)
  • Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). The efficacy ofContinue Reading
  • Gabriel Mbalaviele, Neelam Jaiswal, Anming Meng, Lirong Cheng, C van den Bos, Mark A. Thiede
  • Medicine, Biology
  • Endocrinology
  • 1999 (First Publication: 1 August 1999)
  • Interactions between osteoclast progenitors and stromal cells derived from mesenchymal stem cells (MSCs) within the bone marrow are important for osteoclast differentiation. In vitro models ofContinue Reading
  • Gabriel Mbalaviele, Cynthia D. Sommers, +11 authors Nandini Kishore
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2009 (First Publication: 1 April 2009)
  • Nuclear factor (NF)-κB activation has been clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis. The central role that IκB kinase-2 (IKK-2) plays in regulatingContinue Reading
  • Heidi R Hope, Gary D. Anderson, +14 authors Joseph B. Monahan
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2009 (First Publication: 1 December 2009)
  • Signal transduction through the p38 mitogen-activated protein (MAP) kinase pathway is central to the transcriptional and translational control of cytokine and inflammatory mediator production. p38Continue Reading