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It is known that L-tryptophan stimulates serotonin synthesis in the brain and serotonergic neuronal activity. Also, the N1/P2 component of auditory evoked potential (AEP) is a good indicator of this activity in the auditory cortex. In the present work, we examined the effect of the L-tryptophan administration on electric activity of the auditory cortex(More)
OBJECTIVE To evaluate whether the free fraction of L-tryptophan (L-Trp) and the N1/P2 component of the auditory evoked potentials (AEPs) are associated with impaired brain serotonin neurotransmission in infants with intrauterine growth restriction (IUGR). STUDY DESIGN We measured free, bound, and total plasma L-Trp and recorded the N1/P2 component of AEP(More)
In the course of the present research in school children with insulin-dependent diabetes mellitus, we observed that the free fraction of L-tryptophan, the free fraction of L-tryptophan/total L-tryptophan, and the free fraction of L-tryptophan/neutral amino acids ratios, are significantly reduced. The decrease of free fraction of L-tryptophan in plasma with(More)
In the present study we report results on the possible mechanism of inhibition of tryptophan-5-hydroxylase activity induced by insulin-dependent diabetes mellitus (IDDM). Kinetic experiments were done with different L-tryptophan (L-Trp) concentrations in the rat brain at different days of evolution of the disease. Additionally, different activation(More)
BACKGROUND The present study was aimed to obtain information on the interaction kinetics of L-tryptophan (L-Trp) with plasma albumin from normal, intrauterine growth-restricted (IUGR) and nutritionally recovered (NR) newborn infants. METHODS A case study cohort was planned in 37 newborns during the first 3 months of life. At birth two groups were formed.(More)
In the present work we confirm that gestational malnutrition effects body and brain composition and results in an activation of the synthesis of the brain neurotransmitter 5-hydroxytryptamine. These results also demonstrate more activity of the rate-limiting enzyme tryptophan hydroxylase in the malnourished fetal and postnatal brain. However, the activity(More)
OBJECTIVE To determine in children with type 1 diabetes the plasma free fraction of L-tryptophan (FFT) and the intensity-dependent auditory-evoked potentials (IDAEPs) as indicators of possible changes in brain serotonergic neurotransmission. RESEARCH DESIGN AND METHODS A prospective and comparative study was performed in children with type 1 diabetes and(More)
This study confirms observations made in a former study of plasma of preterm and term newborn infants with intrauterine malnutrition during the first month of life and extends to the lactational period. The free fraction of L-tryptophan, the precursor amino acid of brain serotonin synthesis, is significantly elevated up to 3 months of age. According to(More)
BACKGROUND/AIMS To determine if the slope of the amplitude/stimulus intensity function (ASF) of the N1/P2 component of the auditory evoked potential was increased in women with type 2 diabetes reflecting a low brain serotonergic activity in the auditory cortex. METHODS In a comparative study in women with type 2 diabetes and controls, we measured free,(More)
In the present study we report results concerning 5-hydroxytryptamine (5-HT) metabolism in two groups of small for date (SFD) human babies (gestational age 36 and 3 weeks), who suffered intrauterine nutritional restriction. A complementary study in the brain of rat fetuses with two types of intrauterine deprivation, in which brain L-tryptophan (L-Trp),(More)