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Circadian timekeeping in mammals is driven by transcriptional/posttranslational feedback loops that are active within both peripheral tissues and the circadian pacemaker of the suprachiasmatic nuclei (SCN). Spontaneous synchronization of these molecular loops between SCN neurons is a primary requirement of its pacemaker role and distinguishes it from(More)
Circadian rhythms are essential to health. Their disruption is associated with metabolic diseases in experimental animals and man. Local metabolic rhythms represent an output of tissue-based circadian clocks. Attempts to define how local metabolism is temporally coordinated have focused on gene expression by defining extensive and divergent "circadian(More)
MicroRNAs are often associated with the pathogenesis of many cancers, including head and neck squamous cell carcinoma (HNSCC). In particular, microRNA-21 (miR-21) appears to have a critical role in tumor cell survival, chemoresistance and HNSCC progression. In this study, we investigated matrix hyaluronan (HA)-induced CD44 (a primary HA receptor)(More)
His research involves signal deformation monitoring techniques and analysis for SBAS, GBAS, and the GPS Evolutionary Architecture Study (GEAS). Per Enge, Ph.D., is a professor of aeronautics and astronautics at Stanford University, where he directs the GNSS Research Laboratory. He has been involved in the development of the Federal Aviation Administration's(More)
and is currently working on modernization of the Wide Area Augmentation System (WAAS) and defining future architectures to provide aircraft guidance. Key contributions include early prototype development proving the feasibility of WAAS, significant contribution to the WAAS MOPS, design of ionospheric algorithms for WAAS, and development of dual frequency(More)
and is currently working on modernization of the Wide Area Augmentation System (WAAS) and defining future architectures to provide aircraft guidance. Key contributions include early prototype development proving the feasibility of WAAS, significant contribution to the WAAS MOPS, design of ionospheric algorithms for WAAS, and development of dual frequency(More)
and is currently working on modernization of the Wide Area Augmentation System (WAAS) and defining future architectures to provide aircraft guidance. Key contributions include early prototype development proving the feasibility of WAAS, significant contribution to the WAAS MOPS, design of ionospheric algorithms for WAAS, and development of dual frequency(More)
This review discusses how the T-cell compartment in common variable immunodeficiency is marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. Although B cells have been the main focus of the disorder, ample experimental data suggest that T-cell abnormalities can be seen in a large proportion of Freiburg(More)
  • Stefan Erker, Steffen Thoelert, Michael Meurer, Liang Heng, R Eric Phelts, Xingxin Gao +2 others
  • 2010
W ith the launch of the Delta IV rocket on May 27 from Cape Canaveral Air Force Station the first satellite (space vehicle number 62 or SVN62) of the latest GPS generation Block IIF (F, for " follow-on ") was carried into earth orbit — a major step with roots in the past. Eight years ago in August 2002 the United States decided in coordination with the(More)
Although common variable immunodeficiency (CVID) has long been considered as a group of primary Ab deficiencies, growing experimental data now suggest a global disruption of the entire adaptive immune response in a segment of patients. Oligoclonality of the TCR repertoire was previously demonstrated; however, the manner in which it relates to other B cell(More)