Gabriel Jacobs

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OBJECTIVE AZD6280 is a novel γ-aminobutyric acid A receptor modulator with higher in vitro efficacy at the α2,3 subtypes as compared to the α1 and α5 subtypes. This study compared the pharmacodynamic effects of single oral dose AZD6280 10 mg and 40 mg on the central nervous system with 2 mg of lorazepam. METHODS Sixteen healthy males were enrolled into(More)
The interexaminer reliability of noninvasive methods of examining lumbar spinal segments is not well established. In this project the interexaminer reliability of three experienced chiropractic examiners, who evaluated 21 symptomatic and 25 asymptomatic subjects, was explored. Eight noninvasive segmental examination strategies (dimensions) were employed at(More)
Sixty student volunteers were assessed for fixation in the lumbar spine using a passive motion palpation protocol. Subjects were examined in random order by two experienced chiropractors. Every subject was evaluated twice by each examiner. Fixations were judged present or absent for each of five lumbar motion segments. Moderate test-retest agreement beyond(More)
INTRODUCTION AND PURPOSE Functional proton magnetic resonance spectroscopy (MRS) can be applied to measure pharmacodynamic effects of central nervous system (CNS)-active drugs. The serotonin precursor 5-hydroxytryptophan (5-HTP), administered together with carbidopa and granisetron to improve kinetics and reduce adverse effects, acutely enhances central(More)