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A nursing infant whose mother took alpha-methyldopa (alpha-MD) was followed for 3 months. Analysis of maternal serum and milk as well as the infant's serum and urine for alpha-MD revealed that the drug was excreted into maternal milk, absorbed by the infant and excreted in her urine, but no adverse clinical effects were noted during the follow-up period.(More)
OBJECTIVE To evaluate the relationship between postoperative serum lactate levels and outcome in children undergoing open heart surgery. DESIGN Prospective, noninterventional study. SETTING Pediatric intensive care unit (PICU) of a university hospital. PATIENTS 41 nonconsecutive children who had had cardiopulmonary bypass for repair of congenital(More)
OBJECTIVE To evaluate the relationship of perioperative levels of interleukin 6 (IL-6) in serum and bronchoalveolar fluid with morbidity and mortality in children undergoing cardiopulmonary bypass (CPB). DESIGN Prospective, noninterventional study. SETTING Operating room and pediatric intensive care unit (PICU) of a university hospital. INTERVENTIONS(More)
OBJECTIVES To study the hypothesis that endotoxin and tumor necrosis factor-alpha (TNF) are released into the circulation during the perioperative period in children undergoing open-heart surgery, and to assess the possible role of these factors in postoperative morbidity. DESIGN Prospective study. SETTING Operating room and ICU of a children's(More)
Immobilization hypercalcemia usually causes mild neurologic symptoms. Seizures are a rare complication, appearing weeks after the appearance of other symptoms of hypercalcemia. We report here the case of a 10-year-old boy who developed generalized seizures early in the course of the syndrome. In this child, early diagnosis and therapy probably prevented the(More)
The physiological role of neuropeptide Y (NPY), a sympathetic cotransmitter and vasoconstrictor, has not been determined yet. We used a specific nonpeptide antagonist to the NPY Y1 receptor [BIBP-3226; (R)-N2-(diphenacetyl)-N-[(4-hydroxyphenyl) methyl]-D-arginineamide] to study the involvement of NPY in stress-induced vasoconstriction in the mesenteric bed.(More)
OBJECTIVES To evaluate our experience with propofol anesthesia delivered by pediatric intensivists in the pediatric intensive care unit (PICU) to facilitate elective oncology procedures in children performed by pediatric oncologists. METHODS Elective oncology procedures performed with propofol anesthesia in our multidisciplinary, university-affiliated(More)
Neuropeptide Y (NPY), a sympathetic and platelet-derived vasoconstrictor, acts both directly and by potentiating adrenergic responsiveness and therefore may be beneficial in endotoxic shock, where suppressed vascular responsiveness to adrenergic agents is a key factor. This was studied in anesthetized rats. First, infusion of a nonhypotensive dose of(More)
PURPOSE When radiologists are not available, chest radiographs (CXRs) of pediatric intensive care unit (PICU) patients are commonly interpreted by pediatric intensivists. We prospectively investigated the frequency of errors in CXR interpretation by pediatric intensivists and their impact on patient management. MATERIALS AND METHODS Chest radiographs of(More)
Endotoxin (lipopolysaccharide, LPS)-induced hypotension is, in part, mediated via induction of nitric oxide synthase (iNOS), release of nitric oxide, and suppression of vascular reactivity (vasoplegia). Induction of heat shock proteins (HSP) or inhibition of iNOS expression improves survival in LPS-challenged rodents. We studied the effect of induction of(More)