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killerFLIP: a novel lytic peptide specifically inducing cancer cell death
One of the objectives in the development of effective cancer therapy is induction of tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cellsExpand
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A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR5) are currently being created for clinical cancer therapy, due to their selective killing of cancer cells andExpand
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Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection.
JCPyV and BKPyV are common human polyomaviruses that cause lifelong asymptomatic persistent infections in their hosts. In immunosuppressed individuals, increased replication of JCPyV and BKPyV causeExpand
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Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin
Overexpression of the cellular FLICE-like inhibitory protein (cFLIP) has been reported in a number of tumor types. As an inactive procaspase-8 homologue, cFLIP is recruited to the intracellularExpand