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Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action.
TLDR
A reactivity-guided drug discovery approach for electrophilic natural products, a therapeutically relevant class of natural products that covalently modify their cellular targets, in crude extracts using carefully designed halogenated aromatic reagents. Expand
Discovery, Biosynthesis and Stress-Related Accumulation of Dolabradiene-Derived Defenses in Maize1[OPEN]
TLDR
The findings suggest that dolabralexins have defense-related roles in maize stress interactions and expand the known chemical space of diterpenoid defenses as genetic targets for understanding and ultimately improving maize resilience. Expand
Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.
TLDR
The chemical diversity of five built human habitats together with their occupants is visualize to provide a snapshot of the various molecules to which humans are exposed on a daily basis and indicates that significant transfer of chemicals takes place between us and the authors' built environment. Expand
Multiple genes recruited from hormone pathways partition maize diterpenoid defences
TLDR
The researchers characterized the biosynthetic pathway of an antibiotic diterpenoid in maize and revealed a crosstalk between maize secondary metabolism and gibberellin biosynthesis. Expand
Nature's Combinatorial Biosynthesis Produces Vatiamides A-F.
TLDR
In this work, genome mining combined with the use of a fluorogenic azide-based click probe led to the discovery and characterization of vatiamides A-F, three structurally diverse alkynylated lipopeptides, and their brominated analogues from the cyanobacterium Moorea producens ASI16Jul14-2. Expand
Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.
TLDR
The PI3-kinase/mTOR dual inhibitor neolymphostin A from Salinispora arenicola CNY-486 is the first reported example of a covalent kinase inhibitor from the bacterial domain of life. Expand
Nitrosopyridine Probe To Detect Polyketide Natural Products with Conjugated Alkenes: Discovery of Novodaryamide and Nocarditriene.
TLDR
An optimized nitroso-based probe that facilitates the discovery of conjugated alkene-containing natural products in unprocessed extracts was developed and a new natural product called nocarditriene was discovered, containing an unprecedented epoxy-2,3,4,5-tetrahydropyridine structure from marine-derived Nocardiopsis strain CNY-503. Expand