Gabi Kraemer

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Because it has a role in lymphocyte activation, interleukin 2 (IL-2) has been tried as a therapeutic agent in several types of immune dysfunction in animals and man. Here, Georg Wick and his colleagues discuss the possibility that IL-2 production initiates and perpetuates autoimmune disease, and express caution about the clinical use of IL-2.
BACKGROUND/AIMS Medical treatment for hepatocellular carcinoma (HCC) remains elusive. While an acyclic retinoid improved tumor-free survival after hepatoma resection, tamoxifen finally proved ineffective. Combination therapy of both agents has not been investigated in vitro and in vivo. METHODS MH7777A hepatoma cells were incubated with tamoxifen (TAM)(More)
Ozone (O3) is a toxic gaseous pollutant that has been implicated in laboratory studies as a potential lung carcinogen or cocarcinogen in mice. To begin to assess the role of altered macrophage (M phi) responses as a possible mechanism by which O3 may influence carcinogenesis, we examined the effects of repeated in vivo O3 exposure on pulmonary M phi(More)
In regular beating pacemaker neurons isolated from the sea hare Aplysia californica, 30-50 mM pentylenetetrazol (PTZ) induces spike doublets and triplets, multi-spike bursts, and paroxysmal depolarizing shifts. The development of the characteristic PTZ-induced changes in impluse pattern is preceded by a transient increase in discharge frequency and a(More)
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