Gaëlle Gasan

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Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Taken together, these data suggest a(More)
PURPOSE The purpose was to investigate whether extravascular lung water (EVLW) indexed to actual body weight (EVLWa) is an independent predictor of mortality in patients with septic shock, to determine the relationship between EVLWa and other markers of lung injury, and to test if indexing EVLW with predicted body weight (EVLWp) strengthens its predictive(More)
OBJECTIVE To evaluate the extent to which sitting position and applied positive end-expiratory pressure improve respiratory mechanics of severely obese patients under mechanical ventilation. DESIGN Prospective cohort study. SETTINGS A 15-bed ICU of a tertiary hospital. PARTICIPANTS Fifteen consecutive critically ill patients with a body mass index(More)
INTRODUCTION To investigate whether the difference between sodium and chloride ([Na(+)] - [Cl(-)]) and anion gap corrected for albumin and lactate (AG(corr)) could be used as apparent strong ion difference (SID(app)) and strong ion gap (SIG) surrogates (respectively) in critically ill patients. METHODS A total of 341 patients were prospectively observed;(More)
PURPOSE Acute respiratory failure (ARF) is a common life-threatening complication in morbidly obese patients with obesity hypoventilation syndrome (OHS). We aimed to identify the determinants of noninvasive ventilation (NIV) success or failure for this indication. METHODS We prospectively included 76 consecutive patients with BMI>40 kg/m2 diagnosed with(More)
To investigate the effects of fenofibrate, an activator of peroxysome proliferator activated receptor (PPAR) α, on vascular endothelium and on hemostasis in a rabbit endotoxic shock model. Prospective laboratory study in a university laboratory. 36 male New Zealand rabbits weighing 2.5–3 kg. We determined in vitro vascular reactivity, endothelium(More)
OBJECTIVE To evaluate the impact of switching to total face mask in cases where face mask-delivered noninvasive mechanical ventilation has already failed in do-not-intubate patients in acute respiratory failure. DESIGN AND SETTING Prospective observational study in an ICU and a respiratory stepdown unit over a 12-month study period. INTERVENTION(More)
To assess the time course of the central venous–arterial carbon dioxide tension difference (∆PCO2)—as an index of the carbon dioxide production (VCO2)/cardiac index (CI) ratio—in stable septic shock patients receiving incremental doses of dobutamine. Twenty-two hemodynamically stable septic shock patients with no signs of global tissue hypoxia, as testified(More)
To examine the repeatability of Stewart’s parameters and anion gap in a cohort of critically ill patients and to determine the smallest detectable changes in individual patients. A total of 161 patients were included prospectively. They underwent two subsequent blood samplings within 10 min of each other and samples were analyzed using the same central(More)
BACKGROUND Central venous-to-arterial carbon dioxide partial pressure difference (ΔPCO2) can be used as a marker for the efficacy of venous blood in removing the total CO2 produced by the tissues. To date, this role of ΔPCO2 has been assessed only in patients after resuscitation from septic shock with already normalised central venous oxygen saturation(More)