GP Otto

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The 'systemic inflammatory response syndrome (SIRS)' reflects a non-specific inflammatory reaction to various insults. In sepsis, defined as SIRS triggered by infection, a complex and overwhelming network of mediators contributes to the clinical syndrome. The host response in sepsis is characterized by unspecific physiologic criteria, which are unable to(More)
of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response. Identification of compounds inhibiting the C-S lyase activity of a cell extract from a Staphylococcus sp. isolated from human skin. Lett. Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic(More)
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