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We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and performed genome-wide association testing to identify variants that modify age at onset (AAO) of Alzheimer's disease. Our analysis identified a(More)
The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such large cohorts, we describe here a novel(More)
Several case series showed no evidence of HDV infection among cases of hepatocellular carcinoma, while others reported high levels of infection. ln two case-control studies of hepatocellular carcinoma and HDV infection among subjects seropositive for hepatitis B surface antigen, there were no anti-HD-seropositive individuals among cases or controls. Three(More)
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