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Single-unit recordings from motor cortex (area 4) were obtained in two monkeys trained to perform simple flexion and extension movements of the arm in response to somesthetic, visual, and auditory signals. All neurons tested showed movement-related responses that were identical for equivalent movements irrespective of the modality of the triggering(More)
Single-unit recordings from motor cortex (area 4) were obtained before and after dentate lesion in two monkeys executing fast elbow flexions and extensions in response to randomly presented visual, auditory, and somesthetic stimuli. There were no starting or ending reference points or preparatory signals. Monkeys were trained to perform movements larger(More)
Single-unit recordings were obtained from 404 neurons in the dentate and interposed nuclei in two monkeys trained to perform simple movements of the elbow in response to three different sensory cues: a light, a tone, and a small, brief perturbation of the trained forearm. Both flexion and extension movements were investigated. Those dentate neurons that(More)
This article describes the behavior of motor cortex neurons recorded in macaque monkeys (Macaca mulatta) which had been trained to make extension and flexion movements about the elbow in response to auditory, visual, or somesthetic cues. The pattern of activity of 65% of those movement-related neurons which were recorded during both flexion and extension(More)
Unitary discharge was recorded from 157 cells in area 5 of 2 monkeys trained to perform rapid movements of the contralateral arm. Ninety-six cells were task-related. The earliest movement-related modulation in discharge for the large majority of cells (92%) followed the onset of electromyographic (EMG) activity. The discharge pattern of almost all units for(More)
1. Electrophysiological and morphological (retrograde axonal transport of horseradish peroxidase, HRP) experiments have been carried out in the cat in order to study the associative projections from area SI to ipsilateral SII. 2. Microelectrode recordings were performed in the forepaw focus of SII both in normal (64 units) and in SI-undercut (51 units)(More)
Experiments were performed in unanaesthetized guinea-pigs in order to obtain direct evidence that the noradrenergic projections from locus coeruleus (L.C.) to cerebral cortex inhibit the acetylcholine (ACh) release. The animals were provided with left and right epidural cups, to collect outflowing ACh and with a stimulating electrode, positioned in the left(More)
Microstimulation of the rostral portion of the corpus callosum (CC) was carried out on 21 awake kittens ranging in age from 45 to 105 days to determine the age at which motor responses first appeared and that at which they assumed functional adult-like properties. Motor responses to microstimulation first appeared over an interval ranging from 78-86 days(More)
This study was carry out to obtain direct evidence that the body midline actually is perceived and to assess some psychophysical properties of this line. Twelve normal, right-handed male subjects were asked to make accurate pointing movements toward the midline of the anterior trunk on the basis of their mental representation of this line. Each hand was(More)