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Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis.
About 50% of patients presenting with resectable lung cancer develop distant metastases within 5 years. Genomic markers predicting metastatic behaviour of squamous cell lung carcinoma (SCC) are… Expand
Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia
- E. Nibbeling, A. Duarri, +18 authors D. Verbeek
- Medicine, Biology
- Brain : a journal of neurology
- 1 November 2017
The autosomal dominant cerebellar ataxias, referred to as spinocerebellar ataxias in genetic nomenclature, are a rare group of progressive neurodegenerative disorders characterized by loss of balance… Expand
Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism
Loss of mitochondrial respiratory flux is a hallmark of skeletal muscle aging, contributing to a progressive decline of muscle strength. Endurance exercise alleviates the decrease in respiratory… Expand
A chronic obstructive pulmonary disease related signature in squamous cell lung cancer.
The epidemiological relationship between squamous cell lung cancer (SCC) and chronic obstructive pulmonary disease (COPD), both smoking-related diseases, suggests that they have also a genetic basis.… Expand
Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.
Gene expression profiling of epithelium-associated FcRL4+ B cells in primary Sjögren’s syndrome reveals a pathogenic signature
- G. Verstappen, J. A. Ice, +9 authors F. Kroese
- Chemistry, Medicine
- Journal of autoimmunity
- 19 March 2020
In primary Sjögren’s syndrome (pSS), FcRL4+ B cells are present in inflamed salivary gland tissue, within or in close proximity to ductal epithelium. FcRL4 is also expressed by nearly all pSS-related… Expand
Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice
- A. Martines, A. Gerding, +11 authors Barbara M. Bakker
- Biology, Medicine
- Scientific Reports
- 10 October 2019
During fasting, mitochondrial fatty-acid β-oxidation (mFAO) is essential for the generation of glucose by the liver. Children with a loss-of-function deficiency in the mFAO enzyme medium-chain… Expand
Practical barriers and facilitators experienced by patients, pharmacists and physicians to the implementation of pharmacogenomic screening in Dutch outpatient hospital care - an explorative pilot…
Pharmacogenomics (PGx) can provide optimized treatment to individual patients while potentially reducing healthcare costs. However, widespread implementation remains absent. We performed a pilot… Expand