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Role of AMP-activated protein kinase in mechanism of metformin action.
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production andExpand
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AMPK: an emerging drug target for diabetes and the metabolic syndrome.
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is a key player in regulating energy metabolism, placing it at the center stage in studies of diabetes and related metabolic diseases.Expand
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Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
OBJECTIVE Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide that reduces body weight in obese subjects through increased energyExpand
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Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle; however, theExpand
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Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to serve as agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma). Here, we report theExpand
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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Hitting a dozen enzymes with one drug The adenosine monophosphate-activated protein kinase (AMPK) controls cellular energy status. AMPK is activated when energy levels fall. This stimulates adenosineExpand
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Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.
UNLABELLED Ligand-dependent interactions between nuclear receptors and members of a family of nuclear receptor coactivators are associated with transcriptional activation. Here we used fluorescenceExpand
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AMPK activators – potential therapeutics for metabolic and other diseases
AMP‐activated protein kinase (AMPK)‐mediated cellular metabolic responses to tissue‐specific and whole‐body stimuli play a vital role in the control of energy homeostasis. As a cellularExpand
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Activation of PPARα or γ Reduces Secretion of Matrix Metalloproteinase 9 but Not Interleukin 8 from Human Monocytic THP-1 Cells
Abstract Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that directly control numerous genes of lipid metabolism by binding to response elements in theExpand
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A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux*
The LXR nuclear receptors are intracellular sensors of cholesterol excess and are activated by various oxysterols. LXRs have been shown to regulate multiple genes of lipid metabolism, including ABCA1Expand
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