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Role of AMP-activated protein kinase in mechanism of metformin action.
- G. Zhou, R. Myers, +11 authors D. Moller
- Chemistry, Medicine
- The Journal of clinical investigation
- 15 October 2001
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and… Expand
AMPK: an emerging drug target for diabetes and the metabolic syndrome.
Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is a key player in regulating energy metabolism, placing it at the center stage in studies of diabetes and related metabolic diseases.… Expand
Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
OBJECTIVE Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon receptor (GCGR) dual agonist peptide that reduces body weight in obese subjects through increased energy… Expand
Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle; however, the… Expand
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
Antidiabetic thiazolidinediones (TZDs) and non-TZD compounds have been shown to serve as agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma). Here, we report the… Expand
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Hitting a dozen enzymes with one drug The adenosine monophosphate-activated protein kinase (AMPK) controls cellular energy status. AMPK is activated when energy levels fall. This stimulates adenosine… Expand
Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer.
UNLABELLED Ligand-dependent interactions between nuclear receptors and members of a family of nuclear receptor coactivators are associated with transcriptional activation. Here we used fluorescence… Expand
AMPK activators – potential therapeutics for metabolic and other diseases
AMP‐activated protein kinase (AMPK)‐mediated cellular metabolic responses to tissue‐specific and whole‐body stimuli play a vital role in the control of energy homeostasis. As a cellular… Expand
Activation of PPARα or γ Reduces Secretion of Matrix Metalloproteinase 9 but Not Interleukin 8 from Human Monocytic THP-1 Cells
Abstract Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that directly control numerous genes of lipid metabolism by binding to response elements in the… Expand
A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux*
- C. Sparrow, J. Baffic, +13 authors J. Menke
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 22 March 2002
The LXR nuclear receptors are intracellular sensors of cholesterol excess and are activated by various oxysterols. LXRs have been shown to regulate multiple genes of lipid metabolism, including ABCA1… Expand