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Brd4 Regulation of Papillomavirus Protein E2 Stability
TLDR
A potential role for Brd4 is suggested in regulating E2 stability and protein levels within PV-infected cells after being identified as a potential component of the ubiquitylation machinery that targets both BPV1 and HPV16 E2 for ubiquitylated. Expand
Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease.
TLDR
The results show that constitutive expression of Delta4 in hematopoietic cells impairs the development of B cells, platelets, and early stem cells and induces a lethal lymphoproliferative disease. Expand
Isolation and characterization of the notch ligand delta4.
Notch signaling plays a critical role in a variety of developmental programs. In vertebrates, the complexity of the process is underscored by the existence of multiple Notch receptors and multipleExpand
Sumoylation and Acetylation Play Opposite Roles in the Transactivation of PLAG1 and PLAGL2*
TLDR
The first demonstration that oncoproteins can be regulated by both sumoylation and acetylation is provided, suggesting the essential roles of these sites in the oncogenic potential of PLAG proteins. Expand
Acetylation and alternative splicing regulate ZNF76-mediated transcription.
TLDR
This study shows that ZNF76, a TBP-interacting transcriptional modulator, is regulated by both lysine modifications and alternative splicing. Expand
ZNF76, a Novel Transcriptional Repressor Targeting TATA-binding Protein, Is Modulated by Sumoylation*
TLDR
The results suggest that ZNF76 functions as a transcriptional repressor through its interaction with TBP and that sumoylation modulates its transcriptional repression activity. Expand
Stability of Nmi protein is controlled by its association with Tip60
TLDR
The finding that Tip60 stabilizes Nmi through the formation of distinct cytoplasmic speckles provides a new mechanism to modulate Nmi-mediated functions. Expand
In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates
TLDR
In vitro and in vivo reconstitution experiments revealed that the minimal components are a multivalent RNA-binding protein that concentrates RNAs that are able to form extensive intermolecular mRNA–mRNA interactions. Expand
PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53.
TLDR
It is shown for the first time that Pirh2 forms dimers through its N- and C-terminus in cells andPirh2 dimers interact with PLAGL2, which uncovers a novel function of PLAGl2 as an oncoprotein through regulating the stability of Pirh 2. Expand
Tip60 modulates PLAGL2‐mediated transactivation by acetylation
TLDR
This is the first demonstration that Tip60 can function as a sumoylation inhibitor in part through its intrinsic acetyltransferase activity to regulate specific gene expression. Expand
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