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Effects of Travoprost on Aqueous Humor Dynamics in Patients With Elevated Intraocular Pressure
Travoprost seems to lower intraocular pressure in patients with ocular hypertension or primary open angle glaucoma by increasing trabecular outflow facility, and an effect on uveoscleral outflow cannot be ruled out. Expand
Increase in outflow facility with unoprostone treatment in ocular hypertensive patients.
In responsive patients, unoprostone decreased IOP by increasing outflow facility in responsive patients by studying 33 patients with ocular hypertension or primary open-angle glaucoma. Expand
Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes.
Data indicate that cabergoline's most prominent agonist activity involves activation of 5HT(2),5HT(1A), and D(2/3) receptors, and Cabergoline was an efficacious IOP-lowering agent in normotensive Brown Norway rats. Expand
Potential mechanism for the additivity of pilocarpine and latanoprost.
This randomized, double-masked study included 30 patients with ocular hypertension on no ocular medications for at least 3 weeks to determine the ocular hypotensive mechanism underlying the additivity of latanoprost and pilocarpine. Expand
Aqueous humor dynamics in monkeys with laser-induced glaucoma.
The increased IOP in monkeys with laser-induced glaucoma was caused by a sustained reduction in outflow facility, and the uveoscleral outflow increase was not enough to prevent the rise in IOP. Expand
Bunazosin reduces intraocular pressure in rabbits by increasing uveoscleral outflow.
It is concluded that, in rabbits, 0.1% bunazosin reduces IOP predominantly by increasing uveoscleral outflow, and the role of prostaglandins in this effect is equivocal. Expand
Aqueous humor dynamics during the day and night in healthy mature volunteers.
Nocturnal changes in IOP are independent of the pneumatonometer probe position and are dependent on an individual's posture during the measurement, including reductions in aqueous flow, outflow facility, and possibly uveoscleral outflow. Expand
Effects of Rho Kinase Inhibitors on Intraocular Pressure and Aqueous Humor Dynamics in Nonhuman Primates and Rabbits.
The Y-27632 effect on IOP in hypertensive NHP eyes is caused by increases in outflow facility and uveoscleral outflow, and an increase in aqueous humor formation attenuates but does not prevent an IOP decrease. Expand
Ocular pharmacology of bicyclic hexahydroaporphines.
  • S. Ohia, G. Zhan, +4 authors V. Roche
  • Chemistry, Medicine
  • Methods and findings in experimental and clinical…
  • 1 March 2005
Nor-HHA had no direct contractile or relaxant action on bovine irides, but does cause a concentration-dependent inhibition of carbachol-evoked contractions, implying a role for NO in the postjunctional actions of HHAs. Expand
Prostaglandin-induced iris color darkening. An experimental model.
It is demonstrated that sympathetic innervation is required for age-related, physiologic darkening of iris color in rabbits, that prostaglandins may compensate for sympathetic denervation to produce darkening in SCGx eyes, and that this model may be useful to study prostaglandsin-induced iriscolor change. Expand