G. Zaccara

Publications237
h-index41
Citations5,697
Highly Influential Citations227
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Idiosyncratic Adverse Reactions to Antiepileptic Drugs
Summary:  Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients,…
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Modulation of interhemispheric inhibition by volitional motor activity: an ipsilateral silent period study
TLDR
The findings strongly suggest that voluntary M1 activation by real or imagined movement of the contralateral hand increases interhemispheric motor inhibition of the opposite M1.
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Transcranial magnetic stimulation and epilepsy
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Incidence and predictors of acute symptomatic seizures after stroke
TLDR
The incidence of acute symptomatic seizures is the highest reported in patients with first stroke with prospective follow-up and Hyperlipidemia was a protective factor for hemorrhagic stroke.
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Novel treatment options for epilepsy: focus on perampanel.
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Recommendations of the Italian League Against Epilepsy Working Group on Generic Products of Antiepileptic Drugs
TLDR
It is concluded that generic AEDs meeting current regulatory criteria for bioequivalence represent a valuable choice in the management of epilepsy by allowing a substantial reduction of treatment costs, particularly in patients initiating monotherapy or adjunctive treament and in those with persistent seizures.
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Slow Repetitive TMS for Drug‐resistant Epilepsy: Clinical and EEG Findings of a Placebo‐controlled Trial
Summary:  Purpose: To assess the effectiveness of slow repetitive transcranial magnetic stimulation (rTMS) as an adjunctive treatment for drug‐resistant epilepsy.
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Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs.
  • G. Zaccara, E. Perucca
  • Biology, Medicine
    Epileptic disorders : international epilepsy…
  • 1 December 2014
TLDR
These interactions can have potentially beneficial effects, such as the therapeutic synergism of valproic acid combined with lamotrigine, or adverse effects,such as the reciprocal potentiation of neurotoxicity observed in patients treated with a combination of sodium channel blocking antiepileptic drugs.
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Clinical Pharmacokinetics of Valproic Acid — 1988
TLDR
Sodium valproic acid has been widely used in the last decade and is now considered a relatively safe and effective anticonvulsant agent and its use in the treatment of anxiety, alcoholism and mood disorders, although these indications require further clinical studies.
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Adjunctive lamotrigine therapy in patients with refractory seizures: a lifetime cost–utility analysis
TLDR
Adjunctive lamotrigine in refractory epilepsy seems to have a worse pharmacoeconomic profile than many pharmacological treatments commonly used in areas other than epilepsy.
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