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Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus.
Monacolin K is a secondary metabolite synthesized by polyketide synthases (PKS) from Monascus, and it has the same structure as lovastatin, which is mainly produced by Aspergillus terreus. In theExpand
Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research
Aspergillus section Flavi includes aflatoxin-producing and nonproducing fungi. Aspergillus sojae is unable to produce aflatoxins and is generally recognized as safe for food fermentation. However,Expand
nit-4, a pathway-specific regulatory gene of Neurospora crassa, encodes a protein with a putative binuclear zinc DNA-binding domain.
nit-4, a pathway-specific regulatory gene in the nitrogen circuit of Neurospora crassa, is required for the expression of nit-3 and nit-6, the structural genes which encode nitrate and nitriteExpand
Comparison of the aflR gene sequences of strains in Aspergillus section Flavi.
Aflatoxins are polyketide-derived secondary metabolites produced by Aspergillus parasiticus, Aspergillus flavus, Aspergillus nomius and a few other species. The toxic effects of aflatoxins haveExpand
Differentiation of Aspergillus parasiticus from Aspergillus sojae by random amplification of polymorphic DNA.
Aspergillus parasiticus and Aspergillus sojae are two morphologically similar species belonging to the Aspergillus section flavi. A new method to distinguish the two species, the aflatoxin producerExpand
Secondary metabolites and cytotoxic activities from the endophytic fungus Annulohypoxylon squamulosum
Abstract One new dihydrobenzofuran-2,4-dione derivative, designated as annulosquamulin (1), together with 10 known compounds (2–11), were isolated from the n-BuOH-soluble fraction of the 95% EtOHExpand
Secondary metabolites from the endophytic fungus Biscogniauxia formosana and their antimycobacterial activity
Abstract Two new azaphilone derivatives, namely, biscogniazaphilones A ( 1 ) and B ( 2 ), along with ten known compounds ( 3–12 ), were isolated from the n -BuOH-soluble fraction of the 95% EtOHExpand
Six new metabolites produced by Colletotrichum aotearoa 09F0161, an endophytic fungus isolated from Bredia oldhamii
Six new compounds, colletobredins A–D (1–4) and colletomelleins A and B (5 and 6), along with 12 previously identified compounds, were isolated from the culture broth of Colletotrichum aotearoa BCRCExpand
Monascuspiloin Enhances the Radiation Sensitivity of Human Prostate Cancer Cells by Stimulating Endoplasmic Reticulum Stress and Inducing Autophagy
Prostate cancer is a very common cancer among males. Traditional treatments for prostate cancer have limited efficacy; therefore, new therapeutic strategies and/or new adjuvant drugs must beExpand
Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages.
On cultivation of the fungus Antrodia cinnamomea (BCRC 36799) on a medium, the mycelium was extracted and evaluated for nitric oxide (NO) inhibitory activity. Bioactivity-directed fractionation ledExpand