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Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.
TLDR
It is shown that Mst1 works as both an essential initiator of apoptosis and an inhibitor of hypertrophy in cardiac myocytes, resulting in a previously unrecognized form of cardiomyopathy. Expand
Analysis of alterative cleavage and polyadenylation by 3′ region extraction and deep sequencing
TLDR
Quantitative analysis of APA isoforms indicated that promoter-distal pAs, regardless of intron or exon locations, become more abundant during embryonic development and cell differentiation and that upregulated isoforms have stronger pA, suggesting global modulation of the 3′ end–processing activity in development and differentiation. Expand
Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice
TLDR
It is reported that mice lacking the α6 integrin chain develop to birth, however, they die at birth with severe blistering of the skin and other epithelia, a phenotype reminiscent of the human disorder epidermolysis bullosa. Expand
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.
TLDR
It is reported that mice lacking the alpha 6 integrin chain develop to birth, however, they die at birth with severe blistering of the skin and other epithelia, a phenotype reminiscent of the human disorder epidermolysis bullosa. Expand
Mitogen-activated Protein Kinase Phosphorylates and Targets Inducible cAMP Early Repressor to Ubiquitin-mediated Destruction*
TLDR
A novel cell signaling cross-talk mechanism at the cell nucleus between the MAPK and cAMP pathways, whereby MAPK targets a repressor of the cAMP-dependent gene expression for ubiquitination and proteasomal degradation is presented. Expand
ICER reverses tumorigenesis of rat prostate tumor cells without affecting cell growth
TLDR
The effect of ectopically increasing the expression of ICER on in vitro and in vivo proliferation of the highly metastatic and androgen‐insensitive AT6.3 rat prostate cells is reported. Expand
Transcriptional Regulation of Cyclin D2 by the PKA Pathway and Inducible cAMP Early Repressor in Granulosa Cells1
TLDR
Results showed a CRE within the upstream region of Ccnd2 that is (at least partly) implicated in the stimulation and repression of cyclin D2 transcription, and suggest that ICER involvement in the regulation of granulosa cell proliferation as overexpression of ICER results in the inhibition of PRKACA-induced DNA synthesis. Expand
Inducible cAMP Early Repressor (ICER) Is a Negative-Feedback Regulator of Cardiac Hypertrophy and an Important Mediator of Cardiac Myocyte Apoptosis in Response to &bgr;-Adrenergic Receptor
TLDR
It is suggested that ICER is upregulated by cardiac hypertrophic stimuli increasing CRE- mediated transcription in cardiac myocytes and acts as a negative regulator of hypertrophy and a positive mediator of apoptosis, in part through both inhibition of CRE-mediated transcription and downregulation of Bcl-2. Expand
Cloning of Human Preprotachykinin-I Promoter and the Role of Cyclic Adenosine 5′-Monophosphate Response Elements in Its Expression by IL-1 and Stem Cell Factor1 2
TLDR
It is shown that SCF, a representative cytokine, induced PPT-I and NK-1R leading to autocrine and/or paracrine cell activation, and the results suggest that the presence of CRE sequences within P PT-I promoter could be important in the regulation of PPTI expression by cytokines, irrespective of their ability to signal through cAMP. Expand
A compendium of conserved cleavage and polyadenylation events in mammalian genes.
TLDR
A compendium of conserved cleavage and polyadenylation sites (PASs) in mammalian genes, based on approximately 1.2 billion 3' end sequencing reads from more than 360 human, mouse, and rat samples, shows that ∼80% of mammalian mRNA genes contain at least one conserved PAS, and ∼50% have conserved APA events. Expand
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