Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.
It is shown that Mst1 works as both an essential initiator of apoptosis and an inhibitor of hypertrophy in cardiac myocytes, resulting in a previously unrecognized form of cardiomyopathy.
Analysis of alterative cleavage and polyadenylation by 3′ region extraction and deep sequencing
Quantitative analysis of APA isoforms indicated that promoter-distal pAs, regardless of intron or exon locations, become more abundant during embryonic development and cell differentiation and that upregulated isoforms have stronger pA, suggesting global modulation of the 3′ end–processing activity in development and differentiation.
Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice
- E. Georges‐Labouesse, N. Messaddeq, G. Yehia, L. Cadalbert, A. Dierich, M. L. Meur
- BiologyNature Genetics
- 1 July 1996
It is reported that mice lacking the α6 integrin chain develop to birth, however, they die at birth with severe blistering of the skin and other epithelia, a phenotype reminiscent of the human disorder epidermolysis bullosa.
Dopamine Mediates the Vagal Modulation of the Immune System by Electroacupuncture
It is reported that sciatic nerve activation with electroacupuncture controls systemic inflammation and rescues mice from polymicrobial peritonitis and suggests a new anti-inflammatory mechanism mediated by the sciatic and vagus nerves that modulates the production of catecholamines in the adrenal glands.
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.
- E. Georges‐Labouesse, N. Messaddeq, G. Yehia, L. Cadalbert, A. Dierich, M. Le Meur
- BiologyNature Genetics
It is reported that mice lacking the alpha 6 integrin chain develop to birth, however, they die at birth with severe blistering of the skin and other epithelia, a phenotype reminiscent of the human disorder epidermolysis bullosa.
Mitogen-activated Protein Kinase Phosphorylates and Targets Inducible cAMP Early Repressor to Ubiquitin-mediated Destruction*
- G. Yehia, F. Schlotter, R. Razavi, A. Alessandrini, C. Molina
- Biology, ChemistryJournal of Biological Chemistry
- 21 September 2001
A novel cell signaling cross-talk mechanism at the cell nucleus between the MAPK and cAMP pathways, whereby MAPK targets a repressor of the cAMP-dependent gene expression for ubiquitination and proteasomal degradation is presented.
A compendium of conserved cleavage and polyadenylation events in mammalian genes
A compendium of conserved cleavage and polyadenylation sites (PASs) in mammalian genes, based on approximately 1.2 billion 3' end sequencing reads, reveals sequence motifs surrounding APA sites and a preference of adenosine at the cleavage site, and indicates a mechanism of PAS fixation through evolution of A-rich motifs.
Inducible cAMP Early Repressor (ICER) Is a Negative-Feedback Regulator of Cardiac Hypertrophy and an Important Mediator of Cardiac Myocyte Apoptosis in Response to &bgr;-Adrenergic Receptor…
- H. Tomita, M. Nazmy, K. Kajimoto, G. Yehia, C. Molina, J. Sadoshima
- BiologyCirculation Research
- 11 July 2003
It is suggested that ICER is upregulated by cardiac hypertrophic stimuli increasing CRE- mediated transcription in cardiac myocytes and acts as a negative regulator of hypertrophy and a positive mediator of apoptosis, in part through both inhibition of CRE-mediated transcription and downregulation of Bcl-2.
ICER-IIγ is a tumor suppressor that mediates the antiproliferative activity of cAMP
It is shown that ICER-IIγ dramatically inhibits the growth and DNA synthesis of mouse pituitary tumor cells and human choriocarcinoma cells and that this gene product mediates the antiproliferative activity of cAMP.
The expression of inducible cAMP early repressor (ICER) is altered in prostate cancer cells and reverses the transformed phenotype of the LNCaP prostate tumor cell line.
It was found that cAMP retards LNCaP cell growth; in contrast, cAMP inhibits the growth of PC-3 and DU-145 cells, and deregulation of ICER expression may be related to carcinogenesis of the prostate gland.