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Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia Contributes to Incision-induced Mechanical Allodynia
Background:Recent studies have implicated the activation of stress-activated mitogen-activated protein kinase (MAPK) p38 in spinal microglial cells for development of neuropathic and inflammatoryExpand
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Analysis of Pharmacokinetic Parameters for Assessment of Dextromethorphan Metabolic Phenotypes
In this study, the metabolic ratios of dextromethorphan to dextrorphan (DM/DX) in plasma were calculated at steady state after administering 2 dosage forms (Medicon® and Detusiv®) of DM withExpand
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A minimal stress model for the assessment of electroacupuncture analgesia in rats under halothane
The use of anesthetics in acupuncture analgesia is controversial. We evaluate a steady‐state light anesthesia model to test whether minimal stress manipulation and reliable measurement of analgesiaExpand
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Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine‐addicted mother: Beneficial effect of dextromethorphan
Infants passively exposed to morphine or heroin through their addicted mothers usually develop characteristic withdrawal syndrome of morphine after birth. In such early life, the central nervousExpand
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Checkpoint kinase 1‐mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine‐induced G2/M phase cell‐cycle arrest and apoptosis
In this study, we first demonstrated that loratadine (LOR), a promising world widely used oral anti‐histamine, effectively inhibits growth of tumors derived from human colon cancer cells (COLO 205)Expand
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Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes
Denervation-mediated skeletal muscle atrophy results from the loss of electric stimulation and leads to protein degradation, which is critically regulated by the well-confirmed transcriptionalExpand
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DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and α2-adrenergic receptors
BackgroundDiffuse noxious inhibitory controls (DNIC) can be produced by different types of conditioning stimuli, but the analgesic properties and underlying mechanisms remain unclear. The aim of thisExpand
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Prenatal morphine exposure decreases analgesia but not K+ channel activation
The present study has investigated the possible supraspinal adaptive changes induced by prenatal administration of morphine, including morphine-induced supraspinal antinociception in vivo, theExpand
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The relationship between parental concerns and professional assessment in developmental delay in infants and children--a hospital-based study.
BACKGROUND Developmental delay (DD) in infants and children is one of the chief complaints of parents. It has been established that the concerns of parents are as accurate as quality screening tests.Expand
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Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
Previous investigations had shown that inhibitor of serotonin reuptake transporter (SERT) could attenuate morphine withdrawal syndrome in adult animals. In the present study, we determined whetherExpand
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