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Activation of p38 Mitogen-activated Protein Kinase in Spinal Microglia Contributes to Incision-induced Mechanical Allodynia
TLDR
The results suggest that p38 activation in spinal microglia play a role in incision-induced mechanical allodynia in rats, and p38 inhibition may be useful in treating postsurgical pain.
Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study
TLDR
The findings suggest that ADHD was associated with a previous diagnosis of type 2 DM, and no significant association was observed between ADHD and type 1 DM.
Analysis of Pharmacokinetic Parameters for Assessment of Dextromethorphan Metabolic Phenotypes
TLDR
The metabolic ratio based on the pharmacokinetic parameters of either AUC0-τ,ss, Cmax,ss or Cave,ss and plasma concentrations of DM and DX in a single blood sample at steady state are proposed as an alternative way to identify phenotypes of CYP2D6.
N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.
TLDR
Delayed upregulation of the NMDA receptor-channel complex may be one molecular mechanism that maintains the long-lasting hyperexcitability of hippocampal neurons in kindled animals.
Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine‐addicted mother: Beneficial effect of dextromethorphan
TLDR
It is demonstrated that maternal exposure to morphine decreases the magnitude of PSD‐95, nNOS, the phosphorylation of CREBSerine‐133, and LTD expression in hippocampal CA1 subregion of young offspring, raising a possibility that postsynaptic density proteins could serve an important role, at least in part, for the neurobiological pathogenesis in offspring from the morphine‐addicted mother.
Pulsed radiofrequency inhibited activation of spinal mitogen‐activated protein kinases and ameliorated early neuropathic pain in rats
TLDR
This study aims to elucidate the modulation of PRF on nerve injury‐induced pain development and activation of spinal mitogen‐activated protein kinases (MAPKs) to prevent early neuropathic pain.
Checkpoint kinase 1‐mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine‐induced G2/M phase cell‐cycle arrest and apoptosis
TLDR
The results presented in this study were the first report to describe the Chk1‐mediated G2/M cell‐cycle arrest by the histamine H1 antagonist, LOR.
Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes
TLDR
This pre-clinical in vivo study suggests that PQQ may provide a potent therapeutic benefit for the treatment of denervation-induced atrophy by activating PGC-1α and maintaining the mitochondrial ETC complex in skeletal muscles.
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