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CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity.
TLDR
It is demonstrated that the Csm6 CARF domain is a ring nuclease, whereby bound cA4 is stepwise cleaved initially to ApApApA >p and subsequently to ApA>p in its CARFdomain-binding pocket, with such cleavage bursts using a timer mechanism to regulate the RNase activity of the CSm6 HEPN domain. Expand
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
TLDR
It is shown that the Polycomb Repressor Complex 1 drives colonization of the bones and visceral organs in double-negative prostate cancer (DNPC) and that PRC1 coordinates stemness with immune evasion and neoangiogenesis, pointing to the potential clinical utility of targeting PRC 1 in DNPC. Expand
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.
TLDR
Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells. Expand
Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.
TLDR
It is shown that the human PDF can deformylate its putative substrates derived from mitochondrial DNA-encoded proteins and enzyme kinetics suggest a combined contribution from P2'and P3' positions of a formylated peptide substrate to turnover. Expand
Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity.
TLDR
There was reasonable correlation between spiral formation and inhibition of human MCF-7 breast carcinoma cell growth and omitting GTP from the reaction mixture caused a major change in the morphology of the (-)-rhazinilam-induced polymer. Expand
Anomeric effects of sulfones
The anomeric effect of the sulfone group in tetrahydropyrans has been determined. The value is >2 kcal mol–1, which is larger than the A-value of a methyl group but less than the A-value of theExpand
Brucella abortus phosphoglyceromutase and dihydrodipicolinate reductase induce Th1 and Th2-related immune responses
TLDR
The results demonstrated that the two proteins could induce Th1 and Th2-type immune responses in vivo and in vitro. Expand
A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization
TLDR
It is shown that the genetic loss of Id1/Id3 reduces ocular neovascularization in mouse models of wet age-related macular degeneration and retinopathy of prematurity and may have utility in the management of multiple diseases. Expand
1,2‐Dibromo‐1,1,2,2‐tetrafluoroethane
[124-73-2] C2Br2F4 (MW 259.82) InChI = 1S/C2Br2F4/c3-1(5,6)2(4,7)8 InChIKey = KVBKAPANDHPRDG-UHFFFAOYSA-N (reagent used as a brominating reagent, an alkylating reagent, andExpand
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