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Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.
- Liqun Huang, G. Mackenzie, B. Rigas
- Biology, MedicineCancer research
- 15 December 2011
TLDR
The novel phospho‐non‐steroidal anti‐inflammatory drugs, OXT‐328, MDC‐22 and MDC‐917, inhibit adjuvant‐induced arthritis in rats
- L. Huang, G. Mackenzie, B. Rigas
- MedicineBritish journal of pharmacology
- 1 April 2011
TLDR
Regioselective oxidation of phospho‐NSAIDs by human cytochrome P450 and flavin monooxygenase isoforms: implications for their pharmacokinetic properties and safety
- G. Xie, C. Wong, Ka-Wing Cheng, Liqun Huang, P. Constantinides, B. Rigas
- Biology, MedicineBritish journal of pharmacology
- 1 September 2012
TLDR
Phospho-Ibuprofen (MDC-917) Is a Novel Agent against Colon Cancer: Efficacy, Metabolism, and Pharmacokinetics in Mouse Models
TLDR
Phospho-Sulindac (OXT-328) Combined with Difluoromethylornithine Prevents Colon Cancer in Mice
- G. Mackenzie, N. Ouyang, B. Rigas
- Medicine, BiologyCancer Prevention Research
- 4 April 2011
TLDR
Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.
- Liqun Huang, Cai-hua Zhu, B. Rigas
- Biology, ChemistryCarcinogenesis
- 1 November 2010
TLDR
Phospho-NSAIDs Have Enhanced Efficacy in Mice Lacking Plasma Carboxylesterase: Implications for their Clinical Pharmacology
- C. Wong, Ka-Wing Cheng, B. Rigas
- Biology, MedicinePharmaceutical Research
- 1 May 2015
TLDR
Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.
- G. Mackenzie, Yu Sun, B. Rigas
- Biology, MedicineGastroenterology
- 1 October 2010
BACKGROUND & AIMS
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective cancer chemopreventive agents. However, chronic administration of NSAIDs is associated with significant side effects,…
Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity
- C. Wong, Ka-Wing Cheng, B. Rigas
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 February 2012
TLDR
The metabolism and pharmacokinetics of phospho‐sulindac (OXT‐328) and the effect of difluoromethylornithine
TLDR
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