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Positive and negative selection on the human genome.
The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation in… Expand
Testing the neutral theory of molecular evolution with genomic data from Drosophila
Although positive selection has been detected in many genes, its overall contribution to protein evolution is debatable. If the bulk of molecular evolution is neutral, then the ratio of amino-acid… Expand
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous system… Expand
Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
- S. Dorus, P. Evans, G. Wyckoff, Sun Shim Choi, B. Lahn
- Biology, Medicine
- Nature Genetics
- 1 December 2004
Postcopulatory sperm competition is a key aspect of sexual selection and is believed to drive the rapid evolution of both reproductive physiology and reproduction-related genes. It is… Expand
Rapid evolution of male reproductive genes in the descent of man
A diverse body of morphological and genetic evidence has suggested that traits pertaining to male reproduction may have evolved much more rapidly than other types of character. Recently, DNA sequence… Expand
Human LineageSpecific Amplification, Selection, and Neuronal Expression of DUF1220 Domains
Extreme gene duplication is a major source of evolutionary novelty. A genome-wide survey of gene copy number variation among human and great ape lineages revealed that the most striking human… Expand
A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.
Under prevailing theories, the nonsynonymous-to-synonymous substitution ratio (i.e. K(a)/K(s)), which measures the fixation probability of nonsynonymous mutations, is correlated with the strength of… Expand
The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins.
- M. Barta, N. Dickenson, +5 authors B. Geisbrecht
- Biology, Medicine
- Journal of molecular biology
- 13 April 2012
Many pathogenic Gram-negative bacteria utilize type III secretion systems (T3SSs) to alter the normal functions of target cells. Shigella flexneri uses its T3SS to invade human intestinal cells to… Expand
A universal evolutionary index for amino acid changes.
Different nonsynonymous changes may be under different selective pressure during evolution. Of the 190 possible interchanges among the 20 amino acids, only 75 can be attained by a single-base… Expand
Molecular evolution of functional genes on the mammalian Y chromosome.