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Positive and negative selection on the human genome.
The distinction between deleterious, neutral, and adaptive mutations is a fundamental problem in the study of molecular evolution. Two significant quantities are the fraction of DNA variation inExpand
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Testing the neutral theory of molecular evolution with genomic data from Drosophila
Although positive selection has been detected in many genes, its overall contribution to protein evolution is debatable. If the bulk of molecular evolution is neutral, then the ratio of amino-acidExpand
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Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous systemExpand
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Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
Postcopulatory sperm competition is a key aspect of sexual selection and is believed to drive the rapid evolution of both reproductive physiology and reproduction-related genes. It isExpand
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Rapid evolution of male reproductive genes in the descent of man
A diverse body of morphological and genetic evidence has suggested that traits pertaining to male reproduction may have evolved much more rapidly than other types of character. Recently, DNA sequenceExpand
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Human Lineage–Specific Amplification, Selection, and Neuronal Expression of DUF1220 Domains
Extreme gene duplication is a major source of evolutionary novelty. A genome-wide survey of gene copy number variation among human and great ape lineages revealed that the most striking humanExpand
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A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.
Under prevailing theories, the nonsynonymous-to-synonymous substitution ratio (i.e. K(a)/K(s)), which measures the fixation probability of nonsynonymous mutations, is correlated with the strength ofExpand
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The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins.
Many pathogenic Gram-negative bacteria utilize type III secretion systems (T3SSs) to alter the normal functions of target cells. Shigella flexneri uses its T3SS to invade human intestinal cells toExpand
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A universal evolutionary index for amino acid changes.
Different nonsynonymous changes may be under different selective pressure during evolution. Of the 190 possible interchanges among the 20 amino acids, only 75 can be attained by a single-baseExpand
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Molecular evolution of functional genes on the mammalian Y chromosome.
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