• Publications
  • Influence
Convergent adaptation of human lactase persistence in Africa and Europe
A genotype-phenotype association study in Tanzanians, Kenyans and Sudanese and identified three SNPs that are associated with lactase persistence and that have derived alleles that significantly enhance transcription from the LCT promoter in vitro, providing a marked example of convergent evolution due to strong selective pressure resulting from shared cultural traits.
The evolution of transcriptional regulation in eukaryotes.
The evolutionary dynamics of promoter, or cis-regulatory, sequences and the evolutionary mechanisms that shape them are reviewed.
The evolutionary significance of cis-regulatory mutations
  • G. Wray
  • Biology, Medicine
    Nature Reviews Genetics
  • 1 March 2007
Cases in which parallel mutations have produced parallel trait modifications in particular suggest that some phenotypic changes are more likely to result from cis-regulatory mutations than from coding mutations.
Molecular Evidence for Deep Precambrian Divergences Among Metazoan Phyla
It is suggested that invertebrates diverged from chordates about a billion years ago, about twice as long ago as the Cambrian, which suggests a prolonged radiation of animal phyla.
The Genome of the Sea Urchin Strongylocentrotus purpuratus
The sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus is reported, a model for developmental and systems biology and yields insights into the evolution of deuterostomes.
Parallel Evolution of Nonfeeding Larvae in Echinoids
The switch from feeding to nonfeeding larvae is an ecologically important transfor- mation that has evolved on several separate occasions within the echinoids, and traditional character mapping and a less usual aggregate analysis indicate massively parallel transformations in larval morphology associated with, and only with, this par- ticular life history transformation.
Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears
It is found that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system.
Does evolutionary theory need a rethink?
A broader framework is developed that maintains that important drivers of evolution, ones that cannot be reduced to genes, must be woven into the very fabric of evolutionary theory, and that the EES will shed new light on how organisms grow and develop.
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
The results indicate that positive selection has targeted the regulation of many genes known to be involved in neural development and function, both in the brain and elsewhere in the nervous system, and in nutrition, particularly in glucose metabolism.
Development and application of a phylogenomic toolkit: resolving the evolutionary history of Madagascar's lemurs.
The phylogenomic toolkit is used to develop 11 novel markers from nine chromosomes, representing approximately 9 kb of nuclear sequence data, and yields a data set of more than 16 kb that will be of value to other studies of primate phylogeny and diversification.