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Intraflagellar transport
Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved organelles that project from the surfaces of many cells. The assembly and maintenance of these nearlyExpand
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The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well asExpand
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Proteomic analysis of a eukaryotic cilium
Cilia and flagella are widespread cell organelles that have been highly conserved throughout evolution and play important roles in motility, sensory perception, and the life cycles of eukaryotesExpand
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Chlamydomonas IFT88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg737, Are Required for Assembly of Cilia and Flagella
Intraflagellar transport (IFT) is a rapid movement of multi-subunit protein particles along flagellar microtubules and is required for assembly and maintenance of eukaryotic flagella. We cloned andExpand
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The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance
Approximately 10% of the photoreceptor outer segment (OS) is turned over each day, requiring large amounts of lipid and protein to be moved from the inner segment to the OS. Defects inExpand
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Isolation of Chlamydomonas flagella and flagellar axonemes.
  • G. Witman
  • Chemistry, Medicine
  • Methods in enzymology
  • 1986
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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
The Bardet-Biedl syndrome protein complex (BBSome) is a cargo adapter rather than an essential part of the intraflagellar transport (IFT) machinery.
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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
Entry and exit of proteins into flagella is gauged by CEP290 in the transition zone.
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A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT)
Several enzymes, including cytoplasmic and flagellar outer arm dynein, share an M r 8,000 light chain termed LC8. The function of this chain is unknown, but it is highly conserved between a wideExpand
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The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly
Dyneins are microtubule-based molecular motors involved in many different types of cell movement. Most dynein heavy chains (DHCs) clearly group into cytoplasmic or axonemal isoforms. However, DHC1bExpand
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