• Publications
  • Influence
Benzodiazepines: use, abuse, and consequences.
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MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
The behavioral effects of MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,d)cyclohepten-5,10-imin e], a proposed noncompetitive N-methyl-D-aspartate (NMDA) antagonist, were compared to those ofExpand
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Effects of buprenorphine and other opioid agonists and antagonists on alfentanil- and cocaine-reinforced responding in rhesus monkeys.
Rhesus monkeys self-administered a range of doses of either cocaine or alfentanil under a fixed-ratio 30, time out 45 sec schedule of i.v. drug delivery. Buprenorphine suppressed respondingExpand
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Abuse liability of benzodiazepines.
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Abuse liability of flunitrazepam.
Flunitrazepam is among the most frequently prescribed hypnotics in many countries. Although it was never marketed in the United States, flunitrazepam, in recent years, has been smuggled into theExpand
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Relative reinforcing strength of three N-methyl-D-aspartate antagonists with different onsets of action.
The potential contribution of onset and duration of pharmacological action to the reinforcing strength of three intravenously delivered N-methyl-D-aspartate antagonists was evaluated in this study.Expand
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  • PDF
Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys
Relatively few studies have assessed the reinforcing effects of hallucinogenic compounds, and no such studies have attempted to engender contingent responding for these compounds in animals withExpand
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Differential influence of N-dealkylation on the stimulus properties of some opioid agonists.
The capacity of several opioid agonists and their N-dealkylated derivatives (normetabolites) to substitute for the discriminative and reinforcing stimulus properties of codeine was evaluated inExpand
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Barbiturate-reinforced responding in rhesus monkeys: comparisons of drugs with different durations of action.
The rate and pattern of pressing a lever was studied in rhesus monkeys under conditions where each press led to the intravenous injection of a barbiturate or of saline. The reinforcing effect of theExpand
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