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Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia
Hippocampal atrophy is not specific for AD but is also seen in semantic dementia, and these findings have implications for diagnosis and understanding of the cognitive deficits in AD and semantic dementia. Expand
Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry
Data indicate that VBM will be a valuable technique for in vivo measurement of developing pathology in HD transgenic mice, and may be particularly useful for correlating histologically undetectable changes with behavioral deficits. Expand
Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices
Diffusion tensor imaging was used to investigate changes in anisotropy and diffusivity in survivors of head injury at least 6 months after their injury and the relationship between cognition and diffusion abnormality was investigated. Expand
Analysis of acute traumatic axonal injury using diffusion tensor imaging
Diffusion tensor imaging may help quantify the overall burden of white matter injury in TBI and provide insights into underlying pathophysiology, and Eigenvalue analysis suggests that the early imaging changes seen in white matter are consistent with axonal swelling rather than axonal truncation. Expand
Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.
In TBI, the threshold of CBF below which irreversible tissue damage consistently occurs differs from the classical CBF threshold for stroke (where similar methodology is used to define such thresholds), and the CMRO(2) threshold is comparable to that reported in the stroke literature. Expand
Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
There is predictable atrophy for clinical variants of frontotemporal dementia (FTD), histologic FTD variants show no noticeable differences, and reports of specific atrophy profiles are likely the result of idiosyncrasies in small groups. Expand
Development of a Combined microPET®-MR System
The design of a modified microPET®-MR system for small animal imaging is completed, and assembly and testing is underway, and main features of the modified PET system have been tested. Expand
Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease
MRI with manual volumetry with proof-of-principle for the technique using ex vivo tissue shows the potential of MRI for morphological phenotyping of rodent models of HD and other neurological diseases and carries out in vivo measurement of developing pathology in HD transgenic mice. Expand
Cocaine dependence: a fast-track for brain ageing?
Cocaine-dependent individuals anecdotally appear aged and their mortality rates are estimated up to eight times higher than in the healthy population.1 Psychological and physiological changesExpand
Neuroinflammatory and morphological changes in late-life depression: the NIMROD study
Higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls are found in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Expand