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Metals in cigarette smoke
Metals are vital for a huge number of physiological processes in the human body, but can also destroy health when the concentration is not within the physiologically favourable range. CigaretteExpand
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Glucocorticoid production in the murine thymus
Glucocorticoid hormones are known to act as important modulatory factors in the development of autoimmune diseases, and to play an important role in thymic T‐cell selection. There seems to be aExpand
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Mouse model of venous bypass graft arteriosclerosis.
Saphenous vein grafts are widely used for treatment of severe atherosclerosis via aortocoronary bypass surgery, a procedure often complicated by later occlusion of the graft vessel. Because theExpand
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Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.
Specific antibodies to collagen type IV, laminin, and fibronectin were used to localise these proteins by indirect immunofluorescence in frozen sections of normal and fibrotic liver. In normal liversExpand
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Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress
Hypertension increases mechanical force on the arterial wall by as much as 30%, resulting in marked alterations in signal transductions and gene expression in vascular smooth muscle cells (VSMCs)Expand
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Structure and Biology of the Globular Domain of Basement Membrane Type IV Collagen a
A procedure was developed for purifying the globular domain NC1 of basement membrane collagen from collagenase digests of a variety of tissues. The globule (Mr = 170,000) is a hexameric structureExpand
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T-cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T-cell receptor repertoire
Atherosclerosis is a multifactorial, chronic-inflammatory disease for which the underlying cause remains unknown. It is also well documented that T-cells are among the first cells to migrate into theExpand
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The aging immune system: Primary and secondary alterations of immune reactivity in the elderly
The function of the immune system is known to decline in the elderly. The present communication will show that, similar to the situation in children, it is necessary to distinguish between primaryExpand
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T Regulatory Cells and TH17 Cells in Peri–Silicone Implant Capsular Fibrosis
Background: The authors investigated the immunological mechanisms underlying extensive peri–silicone implant capsule formation, one of the most frequent postoperative complications in patientsExpand
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Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement
Periodontal Ehlers-Danlos syndrome (pEDS) is an autosomal-dominant disorder characterized by early-onset periodontitis leading to premature loss of teeth, joint hypermobility, and mild skin findings.Expand
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