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Second consensus statement on the diagnosis of multiple system atrophy
TLDR
New criteria for diagnosis of multiple system atrophy have simplified the previous criteria, have incorporated current knowledge, and are expected to enhance future assessments of the disease.
Consensus statement on the diagnosis of multiple system atrophy
Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: Status and recommendations The Movement Disorder Society Task Force on rating scales for Parkinson's disease
TLDR
The Movement Disorder Society Task Force for Rating Scales for Parkinson's disease (PD) prepared a critique of the Hoehn and Yahr scale, which recommends that it be used in its original form for demographic presentation of patient groups and in research settings, the HY scale is useful primarily for defining inclusion/exclusion criteria.
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
TLDR
Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome.
SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders
TLDR
This review summarizes the findings of the SIC Task Force for the study of diagnostic criteria for parkinsonian disorders in the areas of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration.
Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
TLDR
It is suggested that TLR4 plays a modulatory role on glial pro‐inflammatory responses and ROS production triggered by α‐synuclein, which may have an impact on understanding the pathogenesis of ASP.
Multiple system atrophy: A review of 203 pathologically proven cases
TLDR
Characteristic glial and/or neuronal cytoplasmic inclusions were identified in all cases in which they were sought, irrespective of clinical presentation, and an association of postural hypotension with intermediolateral cell column degeneration was confirmed.
Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
TLDR
The UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.
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