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Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain.
OBJECTIVE Measures of cholinergic transmitter activity were investigated in patients with autism because of reported neuropathological abnormalities in cholinergic nuclei in the basal forebrain. Expand
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Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors
The function of the cholinergic system is known to change during normal aging and in pathological conditions such as Alzheimer's disease. The present study was designed to assess, within the sameExpand
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Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
Inflammatory processes may play a critical role in the pathogenesis of the degenerative changes and cognitive impairments associated with Alzheimer's disease (AD). In the present study,Expand
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The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress
  • G. Wenk
  • Psychology, Medicine
  • Neurobiology of Learning and Memory
  • 1 March 1997
The nucleus basalis magnocellularis (NBM) contains a population of large cholinergic (Ch) neurons that send their axons to the entire cortical mantle, the olfactory bulbs, and the amygdala. This isExpand
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The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease.
Memantine has been demonstrated to be safe and effective in the symptomatic treatment of Alzheimer's disease (AD). While the neurobiological basis for the therapeutic activity of memantine is notExpand
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Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats
The behavioral, biochemical, histological, and electrophysiological effects of a basal forebrain injection of saporin, a ribosome- inactivating protein, coupled to a monoclonal antibody against theExpand
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Neuropathologic changes in Alzheimer's disease.
  • G. Wenk
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 1 July 2003
Alzheimer's disease is characterized by degenerative changes in a variety of neurotransmitter systems. These include alterations in the function of the monoaminergic neural systems that releaseExpand
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Nucleus basalis magnocellularis and medial septal area lesions differentially impair temporal memory
Functional dissociations between the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM) were examined using the concepts and experimental procedures developed by scalar timingExpand
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Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats
We investigated the ultrastructural, immunohistochemical, biochemical and behavioral effects of chronic neuroinflammation in young rats produced by injection of lipopolysaccharide (LPS) into the 4thExpand
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Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice
3-4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester (NCX-2216), a nitric oxide (NO)-releasing derivative of the cyclooxygenase-1-preferringExpand
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