ASRA Practice Advisory on Local Anesthetic Systemic Toxicity
- J. Neal, C. Bernards, G. Weinberg
- MedicineRegional anesthesia and pain medicine
- 20 December 2009
The American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity assimilates and summarizes current knowledge regarding the prevention, diagnosis,…
Pretreatment or Resuscitation with a Lipid Infusion Shifts the Dose‐Response to Bupivacaine‐induced Asystole in Rats
- G. Weinberg, T. Vadeboncouer, G. Ramaraju, M. F. Garcia-Amaro, M. Cwik
- Medicine, BiologyAnesthesiology
- 1 April 1998
Lipid infusion shifts the dose‐response to bupivacaine‐induced asystole in rats and suggests a potential application for lipid infusion in treating cardiotoxicity resulting from bupvacaine.
Lipid Emulsion Infusion: Resuscitation for Local Anesthetic and Other Drug Overdose
- G. Weinberg
- Medicine, BiologyAnesthesiology
- 1 July 2012
This review will focus on the clinical application of lipid emulsion therapy in resuscitation from drug-related toxicity and provide an introduction to the development of the method, guidelines for its use and insights into potential controversies and future applications.
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?
- D. Feinstein, A. Spagnolo, C. Dello Russo
- BiologyBiochemical Pharmacology
- 15 July 2005
Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer.
- K. Lau, M. Massad, G. Weinberg
- MedicineChest
- 1 November 2011
A novel staging system with prognostic value for EHE is proposed because Pleural effusion or other signs of uncontained tumor growth, hemoptysis, and osseous involvement of more than two bones implied worse survival than did localized and discrete tumors, regardless of number of organs involved.
The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017
- J. Neal, M. Barrington, G. Weinberg
- MedicineRegional anesthesia and pain medicine
- 15 November 2017
This interim update summarizes recent scientific findings that have enhanced the understanding of the mechanisms that lead to lipid emulsion reversal of LAST, including rapid partitioning, direct inotropy, and post-conditioning.
Protective effects of a peroxisome proliferator-activated receptor-β/δ agonist in experimental autoimmune encephalomyelitis
- P. Polak, S. Kalinin, D. Feinstein
- Biology, MedicineJournal of Neuroimmunology
- 1 November 2005
Peroxisome proliferator‐activated receptor‐γ agonists prevent experimental autoimmune encephalomyelitis
- D. Feinstein, E. Galea, M. Heneka
- Biology, Medicine
- 1 June 2002
It is demonstrated in two models of EAE that orally administered PPARγ ligand pioglitazone reduced the incidence and severity of monophasic, chronic disease in C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein peptide and of relapsing disease in B10.Pl mice immunization.
Intravenous lipid emulsion in clinical toxicology
- Leelach Rothschild, S. Bern, Sarah Oswald, G. Weinberg
- MedicineScandinavian Journal of Trauma, Resuscitation and…
- 5 October 2010
Current case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs: beta blockers, calcium channel blockers, parasiticides, herbicides and several varieties of psychotropic agents.
Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac Toxicity
- G. Weinberg, Richard Ripper, D. Feinstein, W. Hoffman
- Medicine, BiologyRegional anesthesia and pain medicine
- 14 January 2003
It was found that infusing a lipid emulsion during resuscitation from bupivacaine-induced cardiac toxicity substantially improved hemodynamics, pmO2, and pHm and increased survival in dogs.
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