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Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.
Findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression. Expand
Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
The cytokine osteopontin (Eta-1), which regulates similar cellular functions, was found to be a protein ligand of CD44, and may be exploited by tumor cells to promote metastasis formation. Expand
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Macrophage proliferation is revealed as a key event in atherosclerosis and macrophage self-renewal is identified as a therapeutic target for cardiovascular disease. Expand
Innate Response Activator B Cells Protect Against Microbial Sepsis
An effector B cell population that protects against microbial sepsis is described that is phenotypically and functionally distinct, develop and diverge from B1a B cells, depend on pattern-recognition receptors, and produce granulocyte-macrophage colony-stimulating factor. Expand
Cytokine storm and sepsis disease pathogenesis
The pathophysiology of the cytokine storm is summarized; the type, effects, and kinetics of cytokine production are described; and new promising therapeutic strategies focusing on the endothelium, as a source and a target of cytokines are described. Expand
Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions
The findings indicate that extramedullary sites supplement the hematopoietic function of the bone marrow by producing circulating inflammatory cells that infiltrate atherosclerotic lesions. Expand
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
The liver is identified as the primary organ that supports rapid erythrocyte removal and iron recycling, and a mechanism by which the body adapts to fluctuations in ery throatcyte integrity is uncovered. Expand
The metastasis gene osteopontin: a candidate target for cancer therapy.
  • G. Weber
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 28 December 2001
Malignant tumors are characterized by dysregulated growth control, overcoming of replicative senescence, and metastasis formation. Current therapeutic regimens mostly exert their effects throughExpand
Phosphorylation‐dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
The data indicate that the activities of distinct osteopontin domains are required to coordinate macrophage migration and activation and may bear on incompletely understood mechanisms of delayed‐type hypersensitivity, wound healing, and granulomatous disease. Expand
An osteopontin splice variant induces anchorage independence in human breast cancer cells
There is evidence for a bifunctional character of osteopontin, with the soluble form supporting invasiveness and the aggregated form promoting adhesion, and a third functional domain is defined, beside the C-terminal CD44- binding site and the central integrin-binding site. Expand