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Aneuploidy detection in single cells using DNA array-based comparative genomic hybridization.
TLDR
A novel approach to manufacture a DNA microarray for CGH for the detection of aneuploidy in single cells requiring just 30 h is reported, which may be more suitable for PGD aneuPLoidy screening than metaphase CGH. Expand
SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with
TLDR
SOLH is a candidate gene for CATM (hereditary cataracts with microphthalmia), which maps in this region, and northern analysis of human tissues revealed a SOLH transcript of approximately 5 kb that was strongest in human brain. Expand
Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim
TLDR
The organization of the mouse Bim gene is investigated, delineating its promoter and splicing, and the gene is positioned on both mouse and human chromosomes to help to clarify the regulation of Bim expression and to assess whether mutations involving Bim contribute to neoplastic and other diseases. Expand
An orphaned mammalian β-globin gene of ancient evolutionary origin
TLDR
Phylogenetic analyses indicate that ω-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds, and it is reported the first report of an orphaned β-like globin gene expressed in a vertebrate. Expand
Isolation of a cDNA clone and localization of the human glutathione S‐transferase 3 genes to chromosome bands 11q13 and 12q13‐14
TLDR
A partial cDNA clone of the glutathione S‐transferase 3 gene (GST3) was obtained by screening a human lung cDNA library with antiserum to human lung GST3 by showing two base differences from the coding sequence of a GST3 cDNA isolated from a human placental c DNA library. Expand
The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
TLDR
In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyRbeta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1, consistent with the recent finding that a mutation in the murines GlyR Beta subunit causes the spa phenotype. Expand
The Aicardi Syndrome in a 47, XXY Male
TLDR
A chromosomal analysis revealed a 47, XXY karyotype in this male, which supports the suggestion that this condition is due to a newly mutated X‐chromosomal dominant gene. Expand
Detection of chromosome 17‐ and X‐bearing human spermatozoa using fluorescence in situ hybridization
Fluorescence in situ hybridization (FISH) with DNA probes specific to chromosomes 17 and the X has been applied to human ejaculated sperm. After sperm nuclei were decondensed with EDTA and DTT,Expand
Localization of the coagulation factor XIII B subunit gene (F13B) to chromosome bands 1q31–32.1 and restriction fragment length polymorphism at the locus
SummaryIn situ hybridization of tritiated cDNA probes for the gene for the B subunit of coagulation factor XIII localized the F13B locus to bands q31–q32.1 on human chromosome 1 and perhaps moreExpand
An orphaned mammalian beta-globin gene of ancient evolutionary origin.
TLDR
Phylogenetic analyses indicate that omega-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds, and it is reported the first report of an orphaned beta-like globin gene expressed in a vertebrate. Expand
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