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Genetic analysis of allergic disease in twins.
TLDR
It is demonstrated that methacholine sensitivity, total serum IgE levels, and total skin test scores to be heritable traits and suggests a genetic contribution to their expression. Expand
HIV DNA and Dementia in Treatment-Naïve HIV-1-Infected Individuals in Bangkok, Thailand
TLDR
From a small subset of individuals, in which adequate number of cells were available, more HIV DNA was in monocytes/macrophages from those with HAD compared to those with ND, thus further implicating HIV DNA in the pathogenesis of HAD. Expand
Concentrations of Circulating Gelatinases (matrix Metalloproteinase-2 and -9) Are Dependent on the Conditions of Blood Collection
A well-defined peak was obtained in the same zone of the 2 region in a dose-dependent fashion. Appearance on AGE was unaffected by the additions (Fig. 1). Iopamidol diluted in CZE buffer solutionExpand
Methacholine inhalation challenge studies in a selected pediatric population.
TLDR
Methacholine challenge studies in pediatric patients must be interpreted with age, personal atopic status, and family asthma history in mind, and there was a difference in the distribution of methacholine Area 35 responses in normal subjects from that in normal families compared withnormal subjects from asthma families. Expand
Lymphocyte glucocorticoid receptors in asthmatic and control subjects
TLDR
The results suggest that the number of lymphocytes glucocorticoid receptors and the apparent affinity of dexamethasone for receptors are not related to the presence or severity of asthma; however, a significant sex effect exists which should be corrected for in future studies of lymphocyte glucocortex receptors. Expand
Protection by ipratropium bromide and metaproterenol against methacholine and histamine bronchoconstriction
TLDR
In the methacholine challenges, both ipratropium bromide and metaproterenol had significant protection as compared to placebo (P<0.001) and in histamine challenges, metaprotserenolHad significant protectionAs compared to the placebo, while ipRatropium Bromide did not protect against histamine. Expand
Common mutation causes cystinosis in the majority of black South African patients
TLDR
It is recommended that black South African and Cape Coloured patients presenting with cystinosis be tested for CTNS-c.971-12G > A in the first instance, with the possibility of prenatal testing being offered to at-risk families. Expand
Methacholine inhalation challenge studies.
TLDR
The dose-response curves and thus the degree of bronchial sensitivity were determined in 19 subjects in a randomized 4-way crossover study and the short-term reproducibility for both methods was good. Expand
Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma.
TLDR
Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchia response is not due to segregation at a single autosomal locus. Expand
Decreased mononuclear cell beta-adrenergic receptors in bronchial asthma: parallel studies of lymphocyte and granulocyte desensitization.
TLDR
The results show that beta-adrenergic receptor density is influenced by cell type, beta- adrenergic agonist administration, and sex; they also show that bronchial asthma itself is associated with lower lymphocyte beta-receptor density. Expand
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