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miR2Disease: a manually curated database for microRNA deregulation in human disease
‘miR2Disease’, a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases. The current version of miR2Disease documents 1939 curatedExpand
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Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
Alcohol exposure during development can cause variable neurofacial deficit and growth retardation known as fetal alcohol spectrum disorders (FASD). The mechanism underlying FASD is not fullyExpand
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Estradiol-regulated microRNAs control estradiol response in breast cancer cells
Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). E2-inducible proteins c-Myc andExpand
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Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury
  • G. Wang, J. Zhang, +7 authors J. Chen
  • Biology, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 14 August 2013
Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific roles of microglia/macrophages in traumatic brainExpand
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Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-base-pair resolution under various physiological conditions. Many aberrant or differentially methylated sitesExpand
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HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
  • G. Wang, Yejie Shi, +11 authors J. Chen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 17 February 2015
Significance Moderate or severe traumatic brain injury (TBI) damages white matter, thereby contributing to long-term neurological deficits. Currently, there are no satisfactory therapies to mitigateExpand
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Prioritization of disease microRNAs through a human phenome-microRNAome network
BackgroundThe identification of disease-related microRNAs is vital for understanding the pathogenesis of diseases at the molecular level, and is critical for designing specific molecular tools forExpand
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n-3 PUFA supplementation benefits microglial responses to myelin pathology
Microglia represent rational but challenging targets for improving white matter integrity because of their dualistic protective and toxic roles. The present study examines the effect of Omega-3Expand
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“Default” Generation of Neonatal Regulatory T Cells
CD4+Foxp3+ regulatory T (Treg) cells were shown to control all aspects of immune responses. How these Treg cells develop is not fully defined, especially in neonates during development of the immuneExpand
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Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis
Background:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was toExpand
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