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Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
The distribution volume ratio (DVR), which is a linear function of receptor availability, is widely used as a model parameter in imaging studies. The DVR corresponds to the ratio of the DV of aExpand
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Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate.
OBJECTIVE The therapeutic effects of methylphenidate in the treatment of attention deficit disorder have been attributed to its ability to increase the synaptic concentration of dopamine by blockingExpand
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Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.
OBJECTIVE The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamineExpand
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Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence
Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significantExpand
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Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.
OBJECTIVE Methamphetamine is a popular and highly addictive drug of abuse that has raised concerns because it has been shown in laboratory animals to be neurotoxic to dopamine terminals. The authorsExpand
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Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain
Methylphenidate (Ritalin) is the most commonly prescribed psychoactive drug in children for the treatment of attention deficit hyperactivity disorder (ADHD), yet the mechanisms responsible for itsExpand
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Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaineExpand
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Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals.
OBJECTIVE Although it is documented that brain dopamine activity declines with age, the functional significance of this is not known. This study assessed the relation between measures of brainExpand
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Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain.
BACKGROUND The purposes of this study were to investigate the pharmacokinetics of methylphenidate hydrochloride (Ritalin) in the human brain, to compare them with those of cocaine, and to evaluateExpand
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Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers.
OBJECTIVE Methamphetamine has raised concerns because it may be neurotoxic to the human brain. Although prior work has focused primarily on the effects of methamphetamine on dopamine cells, there isExpand
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